Evidence map›Paper›PMID 41849392›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Catabolism of serine enantiomers represses enterohemorrhagic

Emily Addington, Kabo R Wale, Emily Horsburgh, Margot Fargeas, Leonidas Spathis, Weronika Leśniak, Saoirse Flavin, Patricia T Rimbi, David R Mark, Sofia Sandalli and 7 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Emily AddingtonSchool of Infection and Immunity, University of Glasgow, Glasgow G12 8TA, United Kingdom.
Kabo R WaleSchool of Infection and Immunity, University of Glasgow, Glasgow G12 8TA, United Kingdom.ORCID 0009-0006-9915-8095
Emily HorsburghSchool of Infection and Immunity, University of Glasgow, Glasgow G12 8TA, United Kingdom.ORCID 0009-0005-2007-4271
Margot FargeasDepartment of Microbiology, School of Genetics and Microbiology, Moyne Institute of Preventive Medicine, Trinity College Dublin, Dublin D02 A2H0, Ireland.ORCID 0009-0003-8577-8718
Leonidas SpathisSchool of Infection and Immunity, University of Glasgow, Glasgow G12 8TA, United Kingdom.ORCID 0000-0003-4788-0132
Weronika LeśniakDepartment of Microbiology, School of Genetics and Microbiology, Moyne Institute of Preventive Medicine, Trinity College Dublin, Dublin D02 A2H0, Ireland.
Saoirse FlavinDepartment of Microbiology, School of Genetics and Microbiology, Moyne Institute of Preventive Medicine, Trinity College Dublin, Dublin D02 A2H0, Ireland.ORCID 0009-0008-7839-6945
Patricia T RimbiSchool of Infection and Immunity, University of Glasgow, Glasgow G12 8TA, United Kingdom.
David R MarkSchool of Infection and Immunity, University of Glasgow, Glasgow G12 8TA, United Kingdom.
Sofia SandalliSchool of Infection and Immunity, University of Glasgow, Glasgow G12 8TA, United Kingdom.
Ester SerranoSchool of Infection and Immunity, University of Glasgow, Glasgow G12 8TA, United Kingdom.ORCID 0000-0001-5075-2954
Gavin BlackburnMVLS Shared Research Facilities, University of Glasgow, Glasgow G12 8QQ, United Kingdom.ORCID 0000-0003-1037-6012
Clément RegnaultMVLS Shared Research Facilities, University of Glasgow, Glasgow G12 8QQ, United Kingdom.
Phillip D WhitfieldMVLS Shared Research Facilities, University of Glasgow, Glasgow G12 8QQ, United Kingdom.ORCID 0000-0002-0814-4119
James P R ConnollyNewcastle University Biosciences Institute, Newcastle University, Newcastle-upon-Tyne NE2 4HH, United Kingdom.ORCID 0000-0002-0394-3413
Andrew J RoeSchool of Infection and Immunity, University of Glasgow, Glasgow G12 8TA, United Kingdom.ORCID 0000-0003-3698-6134
Nicky O'BoyleDepartment of Microbiology, School of Genetics and Microbiology, Moyne Institute of Preventive Medicine, Trinity College Dublin, Dublin D02 A2H0, Ireland.ORCID 0000-0002-8669-7237

Funding

Health Research Board (HRB) EIA-2024-005UKRI | Biotechnology and Biological Sciences Research Council (AFRC) BB/R006539/1UKRI | Biotechnology and Biological Sciences Research Council (AFRC) BB/W015781/1UKRI | Biotechnology and Biological Sciences Research Council (AFRC) UKRI797: 2024BBSRC-DFGUKRI | Medical Research Council (MRC) MR/V011499/1UKRI | Medical Research Council (MRC) MR/X007197/1
6 · The paper itself

Abstract

Attaching and effacing pathogens, including enterohemorrhagic

Indexed as

Enterohemorrhagic Escherichia coliNitrogenSerineVirulence FactorsEscherichia coli ProteinsGene Expression Regulation, BacterialStereoisomerismStress, PhysiologicalType III Secretion SystemsVirulenceEscherichia coli ProteinsNitrogenSerineType III Secretion SystemsVirulence FactorsEHECEscherichia colinitrogen metabolismtype 3 secretion systemvirulence

Identifiers

PMID41849392
PMCPMC13012123

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.