ArticleProceedings of the National Academy of Sciences of the United States of America2026
Targeted NMR signal enhancement of RNA by site-directed bis-nitroxide labeling.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Bimodal Cholesterol for Correlative In-Cell DNP Solid-State NMR and Confocal Microscopy of the Plasma Membrane.Journal of the American Chemical Society · 2026Article
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Authors and funding
7 authors.
Funding
Abstract
MicroRNAs regulate gene expression through sequence-specific interactions with target messenger RNAs (mRNAs), and their misregulation is a hallmark of cancer. MicroRNA-34a (miR-34a), a key modulator of the tumor suppressor p53, binds the mRNA encoding sirtuin 1 (mSirt1) and adopts multiple conformational states that influence repression efficiency. While such dynamics have been characterized in vitro, extending these studies to cellular environments is hampered by weak signals and substantial background inherent to nucleic acid NMR. To overcome this limitation, we developed a site-directed spin labeling strategy for RNA that enables targeted dynamic nuclear polarization (DNP) signal enhancement. Using the bisnitroxide polarizing agent AsymPol-NCS-SDSL, we conjugated spin labels to specific positions of mSirt1 RNA and annealed them to
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