ArticleProceedings of the National Academy of Sciences of the United States of America2026
The SMARCA4-TMEM47 axis plays an essential role in chikungunya virus RNA replication.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- The implications of FASN in viral infection and related diseases: a promising target in antiviral therapies.Frontiers in cellular and infection microbiology · 2026Review
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9 authors.
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Abstract
Chikungunya virus (CHIKV) poses an ongoing threat to global public health. Here, we identified the cBAF complex core ATPase subunit SMARCA4 as a host factor for CHIKV. SMARCA4 acts as a chromatin remodeling factor to license expression of the four-pass transmembrane protein TMEM47. TMEM47 deficiency impairs CHIKV replication in divergent cell types and reduces viral loads and pathological effects following CHIKV infection in mice. TMEM47 interacts with both CHIKV RNA and the nonstructural protein nsP1. Ectopic expression of nsP1 causes a marked redistribution of TMEM47 to the plasma membrane, where it is required for successful assembly of viral replication spherules. We also show that the SMARCA4 inhibitors inhibit CHIKV replication in cells. These findings suggest that the SMARCA4-TMEM47 axis plays an essential role for the completion of the CHIKV life cycle and can be a potential target for anti-CHIKV therapeutics.
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