Evidence map›Paper›PMID 41849381›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

A transcription regulator atlas identifies TOX3 as an Atoh1 coactivator in cerebellar development and tumorigenesis.

Xiaoxin Chen, Xiaochen Zhong, William Yue, Bruce Wang, Brian Woo, Hani Goodarzi, Zaili Luo, Q Richard Lu, Frédéric Flamant, Jeremy F Reiter and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. A transcription regulator atlas identifies TOX3 as an Atoh1 coactivator in cerebellar development and tumorigenesis.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiaoxin ChenCardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94158.ORCID 0000-0003-3092-7010
Xiaochen ZhongCardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94158.
William YueDepartment of Medicine and Division of Gastroenterology, University of California San Francisco, San Francisco, CA 94143.
Bruce WangDepartment of Medicine and Division of Gastroenterology, University of California San Francisco, San Francisco, CA 94143.
Brian WooDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158.
Hani GoodarziDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158.ORCID 0000-0002-9648-8949
Zaili LuoDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35294.
Q Richard LuBrain Tumor Center, Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.ORCID 0000-0001-6846-9014
Frédéric FlamantEcole Normale Supérieure de Lyon, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (INRAE), CNRS, Institut de Génomique Fonctionnelle de Lyon, Lyon 69007, France.ORCID 0000-0002-3360-2345
Jeremy F ReiterDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158.
Guo N HuangCardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94158.ORCID 0000-0002-4335-9123

Funding

Molecular control of cardiac regenerative potentialR01HL138456 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Guo Huang · 2018 to 2026
$5.1M
PB Diversity Supplement Joseph MorenoR01HL160819 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Guo Huang · 2022 to 2026
$3.0M
NHLBI NIH HHS R01 HL138456NHLBI NIH HHS R01 HL160819
6 · The paper itself

Abstract

Organ development and function are orchestrated by intricate transcriptional circuits. Here, we present a comprehensive atlas profiling 1,904 transcription regulators in the brain, cerebellum, heart, kidney, liver, ovary, and testis of fetal, neonatal, and adult mice. Using this dataset, we uncover Thymocyte Selection-Associated High Mobility Group Box Family Member 3 (TOX3) as a potential coactivator of Atoh1 in cerebellar granule neuron progenitors (GNPs).

Indexed as

Basic Helix-Loop-Helix ProteinsCarcinogenesisCerebellar NeoplasmsCerebellumHigh Mobility Group ProteinsAnimalsFemaleGene Expression Regulation, DevelopmentalHumansMaleMedulloblastomaMiceMice, KnockoutAtoh1 protein, mouseBasic Helix-Loop-Helix ProteinsHigh Mobility Group Proteinscerebellar developmentgranule neuron progenitorsmedulloblastomaTOX3transcription factor

Identifiers

PMID41849381
PMCPMC13012119

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.