Evidence map›Paper›PMID 41849380›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

The radical SAM enzyme EpeE exhibits distinct site reactivity during the biosynthesis of the RiPP natural product epipeptide.

William G Walls, Hao Yang, Madeline B Ho, William E Broderick, Brian M Hoffman, Joan B Broderick

Erratum issuedAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

William G WallsDepartment of Chemistry & Biochemistry, Montana State University, Bozeman, MT 59717.
Hao YangDeparment of Chemistry, Northwestern University, Evanston, IL 60208.ORCID 0000-0001-7229-0957
Madeline B HoDeparment of Chemistry, Northwestern University, Evanston, IL 60208.
William E BroderickDepartment of Chemistry & Biochemistry, Montana State University, Bozeman, MT 59717.ORCID 0000-0001-5782-7322
Brian M HoffmanDeparment of Chemistry, Northwestern University, Evanston, IL 60208.ORCID 0000-0002-3100-0746
Joan B BroderickDepartment of Chemistry & Biochemistry, Montana State University, Bozeman, MT 59717.ORCID 0000-0001-7057-9124

Funding

Coboglobins-Cobalt-Substituted Hemoglobins and MyoglobinR01GM111097 · NIGMS · NORTHWESTERN UNIVERSITY · PI HOFFMAN, BRIAN M · 2014 to 2025
$6.7M
Radical SAM Enzymes: Radical Mechanisms Central to BiologyR35GM131889 · NIGMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI Joan B Broderick · 2019 to 2026
$3.0M
HHS | National Institutes of Health (NIH) GM111097HHS | National Institutes of Health (NIH) GM131889National Science Foundation (NSF) MCB-1908587NIGMS NIH HHS R01 GM111097NIGMS NIH HHS R35 GM131889
6 · The paper itself

Abstract

Radical

Indexed as

Bacterial ProteinsBiological ProductsPeptidesS-AdenosylmethionineElectron Spin Resonance SpectroscopyProtein Processing, Post-TranslationalBacterial ProteinsBiological ProductsPeptidesS-AdenosylmethionineepimerizationEPRpeptideradicalS-adenosylmethionine

Identifiers

PMID41849380
PMCPMC13012085

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.