Evidence map›Paper›PMID 41849245›Full record

ReviewActa physiologica (Oxford, England)2026

Deciphering the Presence of Active Interscapular Brown Adipose Tissue in Humans.

Joaquin Sanchez-Gomez, Samuel Ruiz-Campos, Anabel Chica-Perez, Andrés Baena-Raya, Francisco M Acosta, Christian Wolfrum, Patrick C N Rensen, Tania Romacho, Borja Martinez-Tellez

Abstract readReview
In one paragraph

Review in Acta physiologica (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Joaquin Sanchez-GomezDepartment of Nursing, Physiotherapy and Medicine and SPORT Research Group (CTS-1024), CIBIS Research Center, University of Almeria, Almeria, Spain.
Samuel Ruiz-CamposDepartment of Education, Faculty of Education Sciences and SPORT Research Group (CTS-1024), CIBIS Research Center, University of Almería, Almería, Spain.
Anabel Chica-PerezDepartment of Nursing, Physiotherapy and Medicine and SPORT Research Group (CTS-1024), CIBIS Research Center, University of Almeria, Almeria, Spain.
Andrés Baena-RayaDepartment of Education, Faculty of Education Sciences and SPORT Research Group (CTS-1024), CIBIS Research Center, University of Almería, Almería, Spain.
Francisco M AcostaTurku PET Centre, University of Turku, Turku, Finland.
Christian WolfrumLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Patrick C N RensenDepartment of Medicine, Division of Endocrinology and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands.
Tania RomachoDepartment of Nursing, Physiotherapy and Medicine, Chronic Complications of Diabetes Lab (ChroCoDiL), biomedicine, Integrative Physiology and Therapeutics (BIT; CTS-1163), CEINSA Research Center, University of Almeria, Spain.
Borja Martinez-TellezDepartment of Nursing, Physiotherapy and Medicine and SPORT Research Group (CTS-1024), CIBIS Research Center, University of Almeria, Almeria, Spain.ORCID https://orcid.org/0000-0001-8783-1859

Funding

Agencia Estatal de Investigación PID2022-141442OA-I00Agencia Estatal de Investigación RYC2022-035807-IAgencia Estatal de Investigación RYC2022-036473-INovo Nordisk Fonden EASO-New Clinical Investigator Award 2024Novo Nordisk Fonden EFSD-Rising Star 2024
6 · The paper itself

Abstract

Brown adipose tissue (BAT) is increasingly recognized as a metabolically active tissue in humans, although its physiological relevance remains incompletely understood. In rodents, BAT is well characterized, with interscapular BAT (iBAT) representing the main thermogenic depot. In contrast, the existence and persistence of iBAT in adult humans have long been overlooked. In this review, we synthesize anatomical, histological, imaging, and molecular evidence supporting the presence of a potentially active iBAT depot within the dorsocervical subcutaneous adipose tissue in humans. Gene expression and histological studies have conclusively identified dorsocervical subcutaneous adipose tissue as iBAT in human neonates. In adults, the persistence of this depot has been suggested by early histological observations, although definitive molecular confirmation is still lacking. More recent data from HIV-1-infected individuals report increased expression of BAT-related markers in the dorsocervical region; however, histological analyses have not consistently confirmed the presence of iBAT in this population. In parallel, two independent cold-induced

Indexed as

Adipose Tissue, BrownThermogenesisAnimalsFemaleHumansbeige fatbrown fatcardiometabolic healthfemalesexthermoregulation

Identifiers

PMID41849245
PMCPMC12998703

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.