Evidence map›Paper›PMID 41849119›Full record

ReviewDermatology and therapy2026

A Narrative Review of Local Therapies in Hidradenitis Suppurativa: Treatment Landscape and Current Issues.

Elisa Molinelli, Davide Febi, Edoardo De Simoni, Maria Luisa Dragonetti, Irene Richiardi, Matteo Candelora, Daisy Gambini, Sara Belleggia, Guendalina Lucarini, Oriana Simonetti

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Dermatology and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Elisa Molinelli *Dermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, 60126, Ancona, Italy.
Davide Febi *Dermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, 60126, Ancona, Italy.
Edoardo De Simoni *Dermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, 60126, Ancona, Italy. edodesimoni@hotmail.it.ORCID http://orcid.org/0009-0007-8052-9324
Maria Luisa DragonettiDermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, 60126, Ancona, Italy.
Irene RichiardiDermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, 60126, Ancona, Italy.
Matteo CandeloraDermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, 60126, Ancona, Italy.
Daisy GambiniDermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, 60126, Ancona, Italy.
Sara BelleggiaDermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, 60126, Ancona, Italy.
Guendalina LucariniHistology, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, 60126, Ancona, Italy.
Oriana SimonettiDermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, 60126, Ancona, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hidradenitis suppurativa (HS) is an insidious, chronic inflammatory skin disease, leading to a negative impact on a patient's quality of life and a poor prognosis. The pathogenesis of HS is complex and multifaceted including genetic, sex hormones, smoking, obesity, and immune dysregulation as the main contributing factors to the development of the disease. HS is challenging to treat and a multimodal approach, combining topical treatment, systemic therapy, and lifestyle modifications, is a strongly recommended strategy to manage the disease. Regular skin care, topical therapy, and intralesional intervention are the mainstay of the management in HS as monotherapy in mild disease, and in combination with systemic antibiotic or immunomodulatory agents in moderate-to-severe HS. The main aim of this review is to examine local therapeutic interventions that are currently available and under investigation for the treatment of HS.

Indexed as

Antimicrobial washHidradenitis suppurativaIntralesional therapiesTopical antibioticsTopical Janus kinase inhibitor

Identifiers

PMID41849119
PMCPMC13046874

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.