Evidence map›Paper›PMID 41849051›Full record

ReviewArchives of pharmacal research2026

Mechanisms and structure-activity relationship of hypolipidemic effects of polysaccharides from natural resources: a review.

Yao Wu, Yuying Zhang, Chuanming Gong, Bichang Fan, Shuying Li, Jiayi Zhang, Yuze Li, Xiaomei Song, Dongdong Zhang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Archives of pharmacal research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yao WuSchool of Pharmacy, Shaanxi Key Laboratory of Research and Application of "Taibai Qi Yao", Shaanxi University of Chinese Medicine, No.1, Middle Section of Century Avenue, Qindu District, Xianyang, 712046, Shaanxi, P.R. China.
Yuying ZhangSchool of Pharmacy, Shaanxi Key Laboratory of Research and Application of "Taibai Qi Yao", Shaanxi University of Chinese Medicine, No.1, Middle Section of Century Avenue, Qindu District, Xianyang, 712046, Shaanxi, P.R. China.
Chuanming GongSchool of Pharmacy, Shaanxi Key Laboratory of Research and Application of "Taibai Qi Yao", Shaanxi University of Chinese Medicine, No.1, Middle Section of Century Avenue, Qindu District, Xianyang, 712046, Shaanxi, P.R. China.
Bichang FanSchool of Pharmacy, Shaanxi Key Laboratory of Research and Application of "Taibai Qi Yao", Shaanxi University of Chinese Medicine, No.1, Middle Section of Century Avenue, Qindu District, Xianyang, 712046, Shaanxi, P.R. China.
Shuying LiSchool of Pharmacy, Shaanxi Key Laboratory of Research and Application of "Taibai Qi Yao", Shaanxi University of Chinese Medicine, No.1, Middle Section of Century Avenue, Qindu District, Xianyang, 712046, Shaanxi, P.R. China.
Jiayi ZhangSchool of Pharmacy, Shaanxi Key Laboratory of Research and Application of "Taibai Qi Yao", Shaanxi University of Chinese Medicine, No.1, Middle Section of Century Avenue, Qindu District, Xianyang, 712046, Shaanxi, P.R. China.
Yuze LiSchool of Pharmacy, Shaanxi Key Laboratory of Research and Application of "Taibai Qi Yao", Shaanxi University of Chinese Medicine, No.1, Middle Section of Century Avenue, Qindu District, Xianyang, 712046, Shaanxi, P.R. China.
Xiaomei SongSchool of Pharmacy, Shaanxi Key Laboratory of Research and Application of "Taibai Qi Yao", Shaanxi University of Chinese Medicine, No.1, Middle Section of Century Avenue, Qindu District, Xianyang, 712046, Shaanxi, P.R. China.
Dongdong ZhangSchool of Pharmacy, Shaanxi Key Laboratory of Research and Application of "Taibai Qi Yao", Shaanxi University of Chinese Medicine, No.1, Middle Section of Century Avenue, Qindu District, Xianyang, 712046, Shaanxi, P.R. China. zhangnatprod@163.com.ORCID http://orcid.org/0000-0003-0956-1261

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyperlipidemia, characterized by aberrant lipid metabolism, constitutes a pivotal risk factor for cardiovascular diseases (CVDs) and contributes to various metabolic complications. Although conventional lipid-lowering agents are widely used, their long-term clinical application is frequently constrained by adverse side effects. Consequently, natural polysaccharides have attracted significant attention as promising therapeutic candidates due to their potent hypolipidemic effects and favorable safety profiles. This review systematically elucidates the underlying mechanisms by which natural polysaccharides ameliorate hyperlipidemia. Furthermore, the structure-activity relationships (SAR) are critically examined, with particular emphasis on how physicochemical properties such as molecular weight, monosaccharide composition, and chemical modifications modulate biological activity. Finally, current limitations and major bottlenecks in existing research are discussed, and future perspectives are proposed. Collectively, this review provides a reference for the development of novel polysaccharide-based therapeutics for the management of hyperlipidemia.

Indexed as

Biological ProductsHyperlipidemiasHypolipidemic AgentsPolysaccharidesAnimalsHumansLipid MetabolismStructure-Activity RelationshipBiological ProductsHypolipidemic AgentsPolysaccharidesHypolipidemic effectMechanismsPolysaccharidesStructure–activity relationship

Identifiers

PMID41849051

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.