Evidence map›Paper›PMID 41848992›Full record

ArticleDiscover oncology2026

Expression of CSNK1D in lung adenocarcinoma and its prognostic value after surgery.

Chunyuan Chen, Zhu Liang, Biyun Lin, Shuhong Liu, Qu Wang, Yinghuan Xiong, Wei Zhang, Wenmei Su

Abstract read
In one paragraph

Article in Discover oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Chunyuan ChenState Key Laboratory of Mechanism and Quality of Chinese Medicine and Faculty of Chinese Medicine, Macau University of Science and Technology, Taipa, 999078, Macau SAR, China.
Zhu Liang *Department of Thoracic Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.
Biyun Lin *Biotissue Repository, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.
Shuhong LiuDepartment of Thoracic Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.
Qu WangDepartment of Thoracic Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.
Yinghuan XiongBiotissue Repository, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China. xyh821215@163.com.
Wei ZhangState Key Laboratory of Mechanism and Quality of Chinese Medicine and Faculty of Chinese Medicine, Macau University of Science and Technology, Taipa, 999078, Macau SAR, China. wzhang@must.edu.mo.
Wenmei SuState Key Laboratory of Mechanism and Quality of Chinese Medicine and Faculty of Chinese Medicine, Macau University of Science and Technology, Taipa, 999078, Macau SAR, China. suwenmei123@hotmail.com.

Funding

Clinical Research Program, Affiliated Hospital of Guangdong Medical University LCYJ2018B001Cohort Study Program of the Affiliated Hospital of Guangdong Medical University LCYJ2022DL003General Project of Guangdong Provincial Bureau of Traditional Chinese Medicine 2022107Wu Jieping Medical Foundation,China 320.6750.2024-13-75Zhanjiang Competitive Science and Technology Project 2021A05076
6 · The paper itself

Abstract

backgroundCSNK1D is a member of the CK1 family and is characterized by high conservation and widespread expression. It plays a regulatory role in the maintenance of numerous cellular processes and is expressed at low levels in normal tissues but is overexpressed in several types of cancer. All tumor tissues were pathologically diagnosed as lung adenocarcinoma.

methodsImmunohistochemistry (IHC) was used to retrospectively assess CSNK1D expression levels in 90 lung adenocarcinoma surgical tumor tissue microarrays (TMAs). All tumor tissues were pathologically diagnosed as lung adenocarcinoma. An enzyme-linked immunosorbent assay (ELISA) was employed to detect CSNK1D expression in serum samples from 22 lung adenocarcinoma patients. All tumor tissues were pathologically diagnosed as lung adenocarcinoma

resultsCSNK1D was expressed in both the cytoplasm and nucleus, with higher levels in tumor tissues than in adjacent nontumor tissues. The results of survival analysis revealed that high CSNK1D expression was significantly associated with a favorable prognosis. The results of multivariate analysis, adjusted for clinicopathological features, indicated that high CSNK1D expression was an independent predictor of cancer-specific survival.

Indexed as

CSNK1DELISAIHCLUADPrognostic value

Identifiers

PMID41848992
PMCPMC13121649

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