Evidence map›Paper›PMID 41848919›Full record

ArticleClinical & experimental metastasis2026

Predictive factors of response in lung metastases treated by sbrt from colon rectal cancer.

Donatella Caivano, D Pezzulla, P Bonome, F Palmeri, C Scaringi, M Valeriani, D Musio, V de Sanctis, M F Osti

Abstract read
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In one paragraph

Article in Clinical & experimental metastasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Donatella CaivanoTraslational Medicine and Oncology, Department of Medical and Surgical Sciences and Translational Medicine, Faculty of Medicine and Psycology, Sapienza University of Rome, Rome, Italy. donatella.caivano@gmail.com.
D PezzullaRadiation Oncology Unit, Responsible Research Hospital, Campobasso, Italy.
P BonomeRadiation Oncology Unit, Responsible Research Hospital, Campobasso, Italy.
F PalmeriDepartment of Surgical and Medical Sciences and Translational Medicine - Radiology Unit - Sant'Andrea University Hospital, Sapienza - University of Rome, Rome, Italy.
C ScaringiUOC Radiotherapy, San Giovanni Addolorata Hospital, Rome, Italy.
M ValerianiDepartment of Radiation Oncology, Sant' Andrea Hospital, Sapienza Univeristy of Rome, Rome, Italy.
D MusioUOC Radiotherapy, San Giovanni Addolorata Hospital, Rome, Italy.
V de SanctisDepartment of Radiation Oncology, Sant' Andrea Hospital, Sapienza Univeristy of Rome, Rome, Italy.
M F OstiDepartment of Radiation Oncology, Sant' Andrea Hospital, Sapienza Univeristy of Rome, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo identify predictive factors of response in patients with lung metastases from primary colorectal cancer (CRC) treated with stereotactic body radiation therapy (SBRT). This retrospective, single-centre study included patients with histologically confirmed primary CRC, Karnofsky performance status > 60, and age > 18 years. Between 2008 and 2023, 149 lung metastases in 88 patients were treated with SBRT. Among the treated lesions, 23 were synchronous and 126 were metachronous. According to a simplified oligometastatic classification, 9 (6%) were synchronous, 57 (38%) oligorecurrent, 76 (51%) oligoprogressive, and 7 (5%) oligopersistent. Local control (LC) at 1 and 2 years was 76.8% and 64.0%, respectively. Time to polymetastatic conversion (tPMC) at 1 and 2 years was 76.0% and 73.0%. Progression-free survival (PFS) at 1 and 2 years was 76.0% and 73.0%. Overall survival (OS) at 1 and 2 years was 80.7% and 53.0%. On multivariate analysis (MVA), lesion diameter < 16 mm was the only statistically significant favorable prognostic factor for LC. No statistically significant prognostic factors were identified for tPMC or PFS on MVA. For OS, ECOG performance status 0 and female sex were the only statistically significant favorable prognostic factors on MVA. No toxicities ≥ grade 3 were reported. Outcomes and prognostic factors reported herein refer to the present single-centre cohort. In this cohort, SBRT was feasible and was associated with acceptable toxicity and encouraging local control in lung metastases from CRC. Further studies are needed to better define predictive factors and support tailored therapeutic strategies.

Indexed as

Lung NeoplasmsRadiosurgeryRectal NeoplasmsAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesColorectal cancerLung metastasesOligometastatic diseaseSBRT

Identifiers

PMID41848919

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.