ArticleInternational ophthalmology2026
Two current biomarkers in major depressive disorder: peripapillary and subfoveal choroidal vascular indexes.
Article in International ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo investigate the peripapillary (p) and subfoveal (sf) choroidal vascular index (CVI) parameters in newly diagnosed major depressive disorder (MDD).
methodsThis prospective comparative study was conducted on 50 patients with newly diagnosed MDD and 50 age- and sex-matched healthy participants. All participants underwent an ophthalmological examination, and their demographic characteristics were recorded. Choroidal images obtained from the HD-line optical coherence tomography sections of both groups were analyzed in both the foveal and peripapillary regions.Choroidal thickness measurements were obtained, and choroidal vascular parameters were determined using a specialized free software program.These parameters included the luminal choroidal area (LCA), stromal choroidal area (SCA), and total choroidal area (TCA).The ratio of LCA to TCA was defined as CVI.
resultsNo statistically significant differences were found between the groups concerning choroidal thickness, optic disc head measurements, or peripapillary retinal nerve fiber layer thickness (p > 0.05 for all).In the MDD group, the sfLCA was 0.11 ± 0.04 mm
conclusionThe findings highlight the significance of these current, non-invasive, rapid, and reproducible indices obtained through choroidal imaging for elucidating the etiopathogenesis and diagnosis of MDD,a disorder considered to have a neurodegenerative component.
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