Evidence map›Paper›PMID 41848859›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2026

Are birth characteristics related to bone quality measures in young adults? The HUNT study, Norway.

H T Holltrø, T I L Nilsen, B Schei, J Horn, K Holvik, A K N Daltveit, E M Dennison, N C Harvey, A Langhammer, M Hoff

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Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

10 authors.

H T HolltrøDept. of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology, 7491, Trondheim, Norway.
T I L NilsenDepartment of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.
B ScheiDepartment of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.
J HornHUNT Research Centre, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology, Levanger, Norway.
K HolvikDepartment of Physical Health and Ageing, Norwegian Institute of Public Health, Oslo, Norway.
A K N DaltveitDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
E M DennisonMRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK.
N C HarveyMRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK.
A LanghammerHUNT Research Centre, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology, Levanger, Norway.
M HoffDept. of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology, 7491, Trondheim, Norway. mari.hoff@ntnu.no.ORCID http://orcid.org/0000-0002-9992-8663

Funding

Norske Kvinners Sanitetsforening 40027
6 · The paper itself

Abstract

This population-based study investigated the association between birth characteristics and DXA-derived bone quality in 2,680 young adults (aged 20-54 years). Higher birth weight and length were positively associated with bone strength measures, while associations with buckling ratio and hip axis length were weaker and less consistent. PURPOSE: To investigate the association between birth characteristics and bone quality indicators from dual-energy X-ray absorptiometry (DXA) in young adults.

methodsThis population-based study included 2,680 participants (60% women), aged 20-54 years, from the Trøndelag Health Study (HUNT3 and HUNT4), linked with birth data from the Medical Birth Registry of Norway. Birth characteristics included birth weight, birth length, and birth weight relative to gestational age and sex (categorized as small, appropriate, or large for gestational age). Linear regressions assessed associations with bone quality measures, including cross-sectional area, cross-sectional moment of inertia, buckling ratio, and hip axis length. Analyses were adjusted for sex, birth year, age at DXA scan, gestational length, and adult height (for buckling ratio and hip axis length). Additional analyses included bone mineral density (BMD) to assess direct effects.

resultsHigher birth weight and length were positively associated with cross-sectional area and cross-sectional moment of inertia. For each SD increase in birth weight and length, CSA increased by 4.33 and 4.29 mm

conclusionBirth characteristics are associated with both bone strength and geometry in young adulthood. These associations are partly independent of BMD, highlighting the value of DXA-derived bone quality measures in assessing skeletal health.

Indexed as

Birth WeightBone DensityAbsorptiometry, PhotonAdultAnthropometryBody HeightCross-Sectional StudiesFemaleGestational AgeHip JointHumansInfant, Large for Gestational AgeInfant, NewbornInfant, Small for Gestational AgeMaleMiddle AgedBirth characteristicsBone geometryBone mineral densityDual-energy X-rayHip structural analysisSkeletal health

Identifiers

PMID41848859
PMCPMC13553720

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