Evidence map›Paper›PMID 41848844›Full record

SynthesisCalcified tissue international2026

Pregnancy and Lactation Associated Osteoporosis: A Systematic Review.

Zeinab Issa, Randa Saad, Younes Lama, Shahed Ammar, Vanessa Akiki, Christopher S Kovacs, Ghada El-Hajj Fuleihan, Marlene Chakhtoura

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Calcified tissue international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zeinab IssaCalcium Metabolism and Osteoporosis Program, WHO Collaborating Center for Metabolic Bone Disorders, Faculty of Medicine, American University of Beirut-Medical Center, Beirut, Lebanon.
Randa SaadCalcium Metabolism and Osteoporosis Program, WHO Collaborating Center for Metabolic Bone Disorders, Faculty of Medicine, American University of Beirut-Medical Center, Beirut, Lebanon.
Younes LamaCalcium Metabolism and Osteoporosis Program, WHO Collaborating Center for Metabolic Bone Disorders, Faculty of Medicine, American University of Beirut-Medical Center, Beirut, Lebanon.
Shahed AmmarCalcium Metabolism and Osteoporosis Program, WHO Collaborating Center for Metabolic Bone Disorders, Faculty of Medicine, American University of Beirut-Medical Center, Beirut, Lebanon.
Vanessa AkikiCalcium Metabolism and Osteoporosis Program, WHO Collaborating Center for Metabolic Bone Disorders, Faculty of Medicine, American University of Beirut-Medical Center, Beirut, Lebanon.
Christopher S KovacsFaculty of Medicine - Endocrinology, Memorial University of Newfoundland, St. John's, NL, Canada.
Ghada El-Hajj FuleihanCalcium Metabolism and Osteoporosis Program, WHO Collaborating Center for Metabolic Bone Disorders, Faculty of Medicine, American University of Beirut-Medical Center, Beirut, Lebanon.
Marlene ChakhtouraCalcium Metabolism and Osteoporosis Program, WHO Collaborating Center for Metabolic Bone Disorders, Faculty of Medicine, American University of Beirut-Medical Center, Beirut, Lebanon. mc39@aub.edu.lb.ORCID http://orcid.org/0000-0003-0012-986X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pregnancy and lactation-associated osteoporosis (PLO) is a rare disease. It represents a challenge for physicians for diagnosis, treatment and follow up. Our aim is to review fracture data in women with PLO presenting with fragility fractures occurring during late pregnancy or the postpartum/lactation period. We conducted a comprehensive literature search of the following databases: PubMed, MEDLINE and EMBASE from inception until October 2024. We included observational studies and placebo arms of interventional studies assessing fragility fractures at any site among reproductive-age women (18-50 years) during pregnancy, lactation, or up to one year postpartum. We abstracted data and assessed the quality of the included studies in duplicate and independently. We identified 11,375 citations in total, screened 329 full text articles, and included 17 papers from 12 original articles. The mean ± standard deviation (SD) age of women with PLO and fractures in the included studies ranged from 30.6 ± 3.3 to 39.5 ± 6 years. The mean ± SD BMI at the time of diagnosis ranged from 20.9 ± 1.9 to 23.9 ± 3.7 kg/m

Indexed as

LactationOsteoporosisOsteoporotic FracturesPregnancy ComplicationsFemaleHumansPregnancyActation/breastfeedingFragility fracturesPregnancy and lactation-associated osteoporosis (PLO)Systematic review

Identifiers

PMID41848844

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.