Evidence map›Paper›PMID 41848802›Full record

ArticleHead and neck pathology2026

International Consensus Guidelines for Diagnostic Criteria and Checklist for Future Studies for Minimally Invasive Carcinoma ex Pleomorphic Adenoma: An HN CLEAR Initiative.

Beth M Beadle, Nazim Benzerdjeb, Junhun Cho, Valérie Costes-Martineau, William C Faquin, Ricardo Santiago Gomez, Ruta Gupta, Ivana Kholová, Toshitaka Nagao, Swapnil U Rane and 5 more

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Article in Head and neck pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Beth M BeadleDepartment of Radiation Oncology, Stanford University, Stanford, CA, USA.
Nazim BenzerdjebDepartment of Pathology, Institut de Pathologie Multisite, University Hospital of Lyon, Université Claude Bernard Lyon 1, Hospices Civils de Lyon, Lyon, France.
Junhun ChoDepartment of Pathology, Samsung Medical Center, Seoul, Korea.
Valérie Costes-MartineauDepartment of Pathology, University Hospital Montpellier, Montpellier, France.
William C FaquinDepartment of Pathology, Massachusetts General Hospital, Boston, MA, USA.
Ricardo Santiago GomezDepartment of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais and Faculty of Medical Sciences of Minas Gerais, Belo Horizonte, Brazil.
Ruta GuptaFaculty of Health and Medicine, The University of Sydney, Sydney, Australia.
Ivana KholováInstitute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland and Department of Clinical Pathology, Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland.
Toshitaka NagaoDepartment of Anatomic Pathology, Tokyo Medical University, Tokyo, Japan.
Swapnil U RaneDepartment of Pathology, Tata Memorial Centre-Advanced Centre for Training Research and Education in Cancer (TMC-ACTREC), Homi Bhaba National Institute (HBNI), Mumbai, India.
Miguel RitoDepartment of Pathology, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal.
Lester D R ThompsonHead and Neck Pathology Consultations, Woodland Hills, CA, USA.
Spinder SamraDepartment of Tissue Pathology and Diagnostic Oncology, Westmead Hospital, Sydney, Australia.
Peter P LukDepartment of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, NSW Health Pathology, Sydney, Australia.
Simion I ChioseaDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. chioseasi@upmc.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A variety of factors, including the extent of invasion, determine the clinical outcome in patients with carcinoma ex pleomorphic adenoma (Ca ex PA). A Head and Neck Consensus Language for Ease of Reproducibility (HN CLEAR) Steering Committee organized a working group (WG) to harmonize diagnostic and research approaches for assessing invasion in Ca ex PA.WG of head and neck pathologists and a radiation oncologist conducted 6 iterative rounds of online voting (Modified Delphi), using Google Forms, over an 8-month period on invasion in the setting of Ca ex PA. Agreement was defined by the same opinion of at least 50% of the responders. The list of parameters with predetermined options was developed.Minimally invasive Ca ex PA was defined as a pT1-2 pN0 carcinoma, resected en bloc with negative margins, with or without perineural invasion, without vascular invasion and without distant metastasis at presentation. Consensus was not reached on whether high grade histology is compatible with the concept of "minimal invasion". Diagnosis of minimal invasion is possible when tumor excision is complete (with negative margins), en bloc (without fragmentation), and requires sampling of the entire tumor capsule or tumor-normal interface. The consensus guidelines characterizing Ca ex PA and the list of challenging aspects are provided. The WG proposed a checklist for future research, aiming to refine the diagnosis of in situ and minimally invasive Ca ex PA.

Indexed as

Adenoma, PleomorphicCarcinomaSalivary Gland NeoplasmsChecklistConsensusHumansNeoplasm InvasivenessCarcinoma arising in pleomorphic adenomaCarcinoma ex pleomorphic adenomaChecklistConsensusIn situIntracapsularMinimally invasiveNeoplastic processPathologistsReproducibility of resultsSalivary carcinoma

Identifiers

PMID41848802
PMCPMC13000011

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.