ArticleAngewandte Chemie (International ed. in English)2026
o-Terphenyl-Based Family of Conjugated Macrocycles: Selective Recognition of Phenylalanine in Water and Interaction With Insulin.
Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- o-Terphenyl-Based Family of Conjugated Macrocycles: Selective Recognition of Phenylalanine in Water and Interaction With Insulin.Angewandte Chemie (International ed. in English) · 2026Article
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6 authors.
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Abstract
The design of supramolecular receptors for amino acids presents a fundamentally challenging yet highly promising avenue of research. Phenylalanine attracts special attention because of its multifaceted role in living organisms. Although many synthetic hosts have been explored for recognition of phenylalanine (Phe), besides cucurbiturils, there are no receptors that show selectivity for Phe over other aromatic amino acids and related aromatic neurotransmitters in water. Toward addressing this challenge, we explored pi-conjugated water-soluble macrocycles with hydrophobic pockets. A new family of o-terphenyl-based macrocycles, TP[n] (n = 2-8) was synthesized using the Yamamoto reaction. Macrocycles up to the octamer, TP[2]-TP[8], were isolated and fully characterized. X-ray studies reveal that these macrocycles can form folded conformations stabilized by stacking interactions. TP[3] was identified as the most selective host for Phe with an affinity of 7 x 10
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