ArticleACS nano2026
Triterpenoids Bend and Bind Lipid Membranes into 20 nm Stable Nanocages.
Article in ACS nano, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
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Abstract
Achieving a small size without compromising structural stability remains a key challenge in liposome design. Liposomes below 50 nm penetrate barriers more effectively but suffer from curvature-driven instabilities. Here, we introduce a plant-derived triterpenoid as a dual-function molecular modulator that enables the formation of ultrasmall (≈20 nm), thermochemically stable lipid nanocages. Mechanistically, it induces positive membrane curvature to accommodate a small size while reinforcing bilayer cohesion through interlipid hydrogen bonding. This molecular 'glue' effect stabilizes the membrane under extreme curvature, decoupling the classical size-stability trade-off. Molecular dynamics simulations and experiments confirm that this structural remodeling imparts enhanced resistance to heat, pH, and surfactant disruption─conditions that typically destabilize conventional liposomes. These insights suggest potential therapeutic applications, including improved transdermal penetration and preliminary indications of enhanced epidermal regeneration.
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