Evidence map›Paper›PMID 41848512›Full record

ArticleAngewandte Chemie (International ed. in English)2026

Genome-Guided Discovery of Antimalarial 4-Amino-2,4-Pentadienoate-Containing Cyclolipodepsipeptides.

Hartono Candra, Xue-Jiao Wang, Ka Diam Go, Li Feng, Miaomiao Cai, Guang-Lei Ma, Clarissa Widyantoro, Lik Tong Tan, Zbynek Bozdech, Zhe Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hartono CandraSchool of Biological Sciences, Nanyang Technological University, Singapore.
Xue-Jiao WangSchool of Biological Sciences, Nanyang Technological University, Singapore.
Ka Diam GoSchool of Biological Sciences, Nanyang Technological University, Singapore.
Li FengState Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.
Miaomiao CaiCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Guang-Lei MaCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Clarissa WidyantoroNatural Sciences and Science Education, National Institute of Education, Nanyang Technological University, Singapore.
Lik Tong TanNatural Sciences and Science Education, National Institute of Education, Nanyang Technological University, Singapore.
Zbynek BozdechSchool of Biological Sciences, Nanyang Technological University, Singapore.
Zhe WangState Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.
Zhao-Xun LiangSchool of Biological Sciences, Nanyang Technological University, Singapore.ORCID 0000-0002-3128-1330

Funding

CRP NRF-CRP31-0005Ministry of Education of Singapore MOE-T2EP30221-0010
6 · The paper itself

Abstract

4-Amino-2,4-pentadienoate-containing cyclolipodepsipeptides (APD-CLDs) represent a structurally distinctive family of natural products known for their selective activity against hypoxic cancer cells. To explore the structural diversity of APD-CLDs, we have identified and prioritized cryptic APD-CLD biosynthetic gene clusters (BGCs) for compound discovery. Using a combination of genetic and chemical methods, we successfully activated three dormant BGCs, leading to the discovery of 12 new APD-CLDs. These newly discovered metabolites significantly expanded the diversity of the APD-CLD family, with chloromalamides and arabimalamides representing the first halogenated and glycosylated members, respectively. Unexpectedly, chloromalamides and arabimalamides exhibited potent antiplasmodial activity, with IC

Indexed as

AntimalarialsDepsipeptidesDrug DiscoveryPlasmodium falciparumMultigene FamilyAntimalarialsDepsipeptidesantimalarial compoundbiosynthesiscyclolipodepsipeptidenatural productPlasmodium falciparum

Identifiers

PMID41848512
PMCPMC13110770

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.