Evidence map›Paper›PMID 41848353›Full record

ArticleBasic & clinical pharmacology & toxicology2026

6-Nitrodopamine Potentiates Catecholamine-Induced Ca

José Britto-Júnior, Antonio Tiago Lima, Shuaihua Qiao, Hou Fong Tang, Valerie Cardenas, Edson Antunes, Gilberto De Nucci, Albert Ferro

Erratum issuedAbstract read
In one paragraph

Article in Basic & clinical pharmacology & toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Correction to "6-Nitrodopamine Potentiates Catecholamine-Induced CaBasic & clinical pharmacology & toxicology · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

José Britto-JúniorFaculty of Life Sciences and Medicine, School of Cardiovascular and Metabolic Medicine & Sciences, British Heart Foundation Centre of Research Excellence, King's College London, UK.ORCID https://orcid.org/0000-0003-0250-8468
Antonio Tiago LimaFaculty of Medical Sciences, Department of Pharmacology, University of Campinas (UNICAMP), Campinas, Brazil.
Shuaihua QiaoFaculty of Life Sciences and Medicine, School of Cardiovascular and Metabolic Medicine & Sciences, British Heart Foundation Centre of Research Excellence, King's College London, UK.
Hou Fong TangFaculty of Life Sciences and Medicine, School of Cardiovascular and Metabolic Medicine & Sciences, British Heart Foundation Centre of Research Excellence, King's College London, UK.
Valerie CardenasFaculty of Life Sciences and Medicine, School of Cardiovascular and Metabolic Medicine & Sciences, British Heart Foundation Centre of Research Excellence, King's College London, UK.
Edson AntunesFaculty of Medical Sciences, Department of Pharmacology, University of Campinas (UNICAMP), Campinas, Brazil.
Gilberto De NucciFaculty of Medical Sciences, Department of Pharmacology, University of Campinas (UNICAMP), Campinas, Brazil.ORCID https://orcid.org/0000-0002-4346-7941
Albert FerroFaculty of Life Sciences and Medicine, School of Cardiovascular and Metabolic Medicine & Sciences, British Heart Foundation Centre of Research Excellence, King's College London, UK.

Funding

British Heart Foundation Centre for Excellence Award RE/18/2/34213National Council for Scientific and Technological Development (CNPq) 303839/2019-8 (G.D.N.).Sao Paulo Research Foundation (FAPESP) 2019/16805-4 (G.D.N.)Sao Paulo Research Foundation (FAPESP) 2021/1393-6 (A.T.L.)Sao Paulo Research Foundation (FAPESP) 2021/14414-8 (J.B.-J.)Sao Paulo Research Foundation (FAPESP) 2023/14557-9
6 · The paper itself

Abstract

backgroundIn vascular smooth muscle, rises in intracellular calcium [Ca

methodsHuman aortic smooth muscle cells (HASMCs) were loaded with fura-2 AM (1 μM) and [Ca

results6-ND and classical catecholamines evoked concentration-dependent increases in HASMC Ca

conclusions6-ND is a potent modulator of [Ca

Indexed as

CalciumCatecholaminesDopamineMuscle, Smooth, VascularAnimalsAortaAorta, ThoracicCalcium SignalingCells, CulturedDose-Response Relationship, DrugHumansMaleMuscle ContractionMyocytes, Smooth MuscleRatsVasoconstrictionCalciumCatecholaminesDopaminecAMPcyclase associated proteinshypertensionnitrocatecholaminesynergism

Identifiers

PMID41848353
PMCPMC12998412

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.