Evidence map›Paper›PMID 41848316›Full record

ArticleMicrobiology spectrum2026

Metabolic activation of pyruvate cycle by protocatechualdehyde triggers oxidative killing of ampicillin-resistant

Liting Cheng, Yue Liu, Yifei Ge, Shuhan Yang, Tao Yuan, Sufang Kuang

Erratum issuedAbstract read
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Liting ChengJiangxi Province Key Laboratory of Natural and Biomimetic Drugs Research, College of Pharmacy, Jiangxi Normal University, Nanchang, Jiangxi, China.ORCID 0009-0009-4393-0420
Yue LiuCollege of Life Sciences, Jiangxi Normal University, Nanchang, China.
Yifei GeJiangxi Province Key Laboratory of Natural and Biomimetic Drugs Research, College of Pharmacy, Jiangxi Normal University, Nanchang, Jiangxi, China.
Shuhan YangJiangxi Province Key Laboratory of Natural and Biomimetic Drugs Research, College of Pharmacy, Jiangxi Normal University, Nanchang, Jiangxi, China.
Tao YuanJiangxi Province Key Laboratory of Natural and Biomimetic Drugs Research, College of Pharmacy, Jiangxi Normal University, Nanchang, Jiangxi, China.ORCID 0000-0001-7746-3714
Sufang KuangJiangxi Province Key Laboratory of Natural and Biomimetic Drugs Research, College of Pharmacy, Jiangxi Normal University, Nanchang, Jiangxi, China.ORCID 0009-0009-4527-077X

Funding

Jiangxi Normal University Doctoral Research Fund 12022819Jiangxi Province Key Laboratory of Natural and Biomimetic Drugs Research Fund 2024SSY07051National Natural Science Foundation of China 22207050National Natural Science Foundation of China 22477048Natural Science Foundation of Jiangxi Province 20252BAC200362
6 · The paper itself

Abstract

Antimicrobial resistance has emerged as a major global public health threat, underscoring the urgent need for novel therapeutic strategies. In this study, we demonstrate that protocatechualdehyde (PA), a natural compound derived from

Indexed as

Anti-Bacterial AgentsBenzaldehydesCatecholsEscherichia coliPyruvic AcidAmpicillinAmpicillin ResistanceDrug Resistance, Multiple, BacterialKlebsiella pneumoniaeMicrobial Sensitivity TestsPseudomonas aeruginosaReactive Oxygen SpeciesSalvia miltiorrhizaAmpicillinAnti-Bacterial AgentsBenzaldehydesCatecholsprotocatechualdehydePyruvic AcidReactive Oxygen Speciesampicillin-resistant Escherichia colimetabolic regulationnatural compoundpyruvate metabolism

Identifiers

PMID41848316
PMCPMC13055212

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.