Evidence map›Paper›PMID 41848236›Full record

ArticleOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2026

Opioid Dependency After Craniomaxillofacial Trauma Surgery.

Amrita Hari-Raj, Sai D Challapalli, Matt Keller, Joanna Buss, Dorina Kallogjeri, Jay F Piccirillo, Emily A Spataro

Abstract read
In one paragraph

Article in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amrita Hari-RajDepartment of Otolaryngology-Head & Neck Surgery, Washington University in St. Louis, St. Louis, Missouri, USA.ORCID https://orcid.org/0000-0003-2469-2745
Sai D ChallapalliDepartment of Otolaryngology-Head & Neck Surgery, Division of Facial Plastic & Reconstructive Surgery, Washington University in St. Louis, St. Louis, Missouri, USA.
Matt KellerDepartment of Medicine, Institute of Clinical & Translational Sciences, Center for Administrative Data Research, Washington University in St. Louis, St. Louis, Missouri, USA.
Joanna BussDepartment of Medicine, Institute of Clinical & Translational Sciences, Center for Administrative Data Research, Washington University in St. Louis, St. Louis, Missouri, USA.
Dorina KallogjeriDepartment of Otolaryngology-Head & Neck Surgery, Washington University in St. Louis, St. Louis, Missouri, USA.
Jay F PiccirilloDepartment of Otolaryngology-Head & Neck Surgery, Washington University in St. Louis, St. Louis, Missouri, USA.
Emily A SpataroDepartment of Otolaryngology-Head & Neck Surgery, Division of Facial Plastic & Reconstructive Surgery, Washington University in St. Louis, St. Louis, Missouri, USA.

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Otolaryngology R25 Mentored Research Pathway at Washington UniversityR25DC020706 · NIDCD · WASHINGTON UNIVERSITY · PI Jay F. Piccirillo · 2023 to 2026
$1.6M
Foundation for Barnes-Jewish Hospital 6648NCATS NIH HHS UL1 TR002345NIDCD NIH HHS R25 DC020706NIDCD NIH HHS R25DC020706
6 · The paper itself

Abstract

objectiveThe opioid crisis has led to significant morbidity and mortality. A component of this is attributable to overdoses on prescribed opioids. A prior study estimated that 39% of opioid prescriptions after craniomaxillofacial (CMF) trauma were potentially inappropriate prescriptions. The goal of this study was to identify factors associated with potentially inappropriate and prolonged opioid prescriptions in the postoperative CMF trauma patient population. STUDY

designRetrospective cohort.

settingMerative™ MarketScan® Commercial & Multi-State Medicaid Databases (2015-2022).

methodsPatients undergoing CMF trauma surgery were identified and stratified based on whether they had commercial versus Medicaid insurance. The association of prolonged opioid prescription length with demographic, comorbid, and surgical factors was investigated.

resultsA total of 23,985 patients from 2015 to 2022 underwent CMF trauma surgery and received postoperative opioid prescriptions. The average prescription length was significantly lower in the commercially insured cohort versus the Medicaid cohort (24.6 days vs 33.7 days), and 22% of prescriptions were potentially inappropriate in nature. A diagnosis of chronic pain, as well as having 2 overlapping opioid prescriptions or an extended-release opioid prescription, had the highest adjusted odds of a prescription longer than 30 days.

conclusionAlthough potentially inappropriate prescriptions after CMF trauma surgery decreased from a prior estimate (39% vs 22%), inappropriate prescribing practices are highly associated with prolonged opioid prescriptions. Providers must ensure patients do not have an existing opioid prescription before writing an additional one and should not dispense extended-release formulations in the acute postoperative setting.

Indexed as

Analgesics, OpioidFacial InjuriesInappropriate PrescribingOpioid-Related DisordersPostoperative PainAdultFemaleHumansMaleMiddle AgedRetrospective StudiesUnited StatesAnalgesics, Opioidcraniomaxillofacial traumafacial plastic and reconstructive surgeryfacial traumaopioidspain management

Identifiers

PMID41848236
PMCPMC13060026

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.