Evidence map›Paper›PMID 41848105›Full record

Trial reportCancer2026

Valued Living intervention to increase advance care planning and well-being in depressed and anxious adults with advanced cancer: Randomized trial in community oncology clinics.

Joanna J Arch, Jill L Mitchell, Sarah J Schmiege, Michael E Levin, Madeline S Nealis, Sarah R Genung, Regina M Fink, David J Andorsky, Jean S Kutner

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04773639 (Randomized Clinical Trial of a Multi-Modal Palliative Care Intervention), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04773639 nacompletednot on this map

Randomized Clinical Trial of a Multi-Modal Palliative Care Intervention

TypeinterventionalSponsorUniversity of Colorado, BoulderRan2021 to 2025Enrolled240ConditionsDepression, Anxiety, Metastatic CancerArmsMulti-Modal Palliative Care Intervention, Usual Care Control Condition
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Joanna J ArchDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado, USA.ORCID https://orcid.org/0000-0002-6702-095X
Jill L MitchellRocky Mountain Cancer Centers, Greenwood Village, CO, USA.
Sarah J SchmiegeDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Center, Aurora, Colorado, USA.
Michael E LevinDepartment of Psychology, Utah State University, Logan, Utah, USA.
Madeline S NealisDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado, USA.
Sarah R GenungDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado, USA.
Regina M FinkUniversity of Colorado College of Nursing, Anschutz Medical Campus, Aurora, Colorado, USA.
David J AndorskyRocky Mountain Cancer Centers, Greenwood Village, CO, USA.
Jean S KutnerDivision of General Internal Medicine, Department of Medicine, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado, USA.

Funding

Randomized clinical trial of a multi-modal palliative care interventionR01NR018479 · NINR · UNIVERSITY OF COLORADO · PI ARCH, JOANNA J · 2020 to 2024
$2.5M
NIH HHS R01NR018479
6 · The paper itself

Abstract

backgroundAdults with advanced cancer often experience low engagement with advance care planning (ACP) and high levels of depression, anxiety, and fear of death/dying. Access to specialist palliative care is limited. This study tests Valued Living, a novel online acceptance-based group intervention designed to increase ACP and improve psychological/spiritual well-being among adults with advanced cancer screening positive for depression or anxiety. Valued Living was delivered online by social workers in community oncology settings.

methodsAdults with advanced solid tumor cancer (N = 240) and significant depression or anxiety symptoms were randomized 1:1 within cohorts to Valued Living or usual care (UC). Valued Living provided five weekly group sessions by videoconference plus self-paced online modules. Primary outcome was the total number of ACP behavioral steps completed of 12 potential steps (e.g., selecting health care proxy, advanced directives) by 3.5-month follow-up. Secondary outcomes included fear of death, rigid cognitive avoidance of death, depression, anxiety, and spiritual well-being.

resultsValued Living participants completed 1.27 more ACP steps (95% CI, 0.36-2.18; d = 0.36; p = .006) than UC. Largest condition differences were identifying (97.4% vs. 84.2%) and documenting a health care proxy (83.3% vs. 64.9%). Valued Living participants improved more in cognitive avoidance of death (d = 0.36; p = .005), and spiritual well-being (d = 0.42; p < .001) but not fear of death or anxiety.

conclusionThe online Valued Living intervention, implemented by social workers in community oncology clinics, increased ACP and well-being among depressed and anxious adults with advanced cancer. Findings support this supportive care approach for the growing population living with advanced cancer.

trial registrationThe trial registration is ClinicalTrials.gov NCT04773639.

Indexed as

Advance Care PlanningAnxietyDepressionNeoplasmsAdultAgedFemaleHumansMaleMiddle AgedPalliative CarePsychological Well-Beingacceptance and commitment therapyadvance care planninganxietycommunity health servicesdepressionneoplasmsneoplasms/advanced stageoncologypsycho‐oncologysupportive care

Identifiers

PMID41848105
PMCPMC12997518

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.