ArticleJournal of the American Heart Association2026
From Empirical to More Precise Correction: Multidimensional Performance Evaluation of QTc Formulas in a Cohort of Healthy Asian Youth.
Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Obesity and shorter QT intervals: sex- and adiposity distribution-specific patterns of ventricular repolarization in healthy Asian youth.BMC cardiovascular disorders · 2026Observational
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Authors and funding
7 authors.
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Abstract
backgroundThe Bazett formula remains widely used for QT interval corrected for heart rate (HR) despite its limitations, yet its performance in healthy Asian youth is poorly characterized, necessitating a systematic evaluation against alternatives.
methodsThis cross-sectional study included 3258 healthy Asian individuals aged 18 to 22 years. QT interval corrected for HR was calculated using 6 formulas (Bazett, Fridericia, Framingham, Hodges, Rautaharju, Dmitrienko). Interformula consistency (Bland-Altman analysis), HR dependence (Spearman correlation), and HR's effect modification (generalized estimating equations) were assessed. Clinical equivalence (mean absolute deviation, ≤5 ms) was evaluated within HR subgroups (<60, 60-100, >100 bpm).
resultsBazett showed the strongest HR dependence (ρ=0.268) and poorest consistency (eg, mean absolute deviation versus Fridericia, 14.10 ms). Dmitrienko exhibited optimal HR independence (ρ=0.064). Framingham and Rautaharju demonstrated the highest agreement (bias, 0.395 ms). HR was the dominant effect modifier for all formula pairs (all interaction
conclusionsFor healthy Asian youth, the Framingham formula provides the most consistent and HR-robust QT interval corrected for HR estimation, supporting its use as a unified standard, particularly at low and normal HRs. Bazett's significant overestimation at high HRs warrants caution. These findings advocate for an evidence-based shift from Bazett toward precision QT interval corrected for HR.
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