ArticleJournal of the American Heart Association2026
Clinical, Functional, and Quality-of-Life Outcomes After Contemporary Transcatheter Edge-to-Edge Repair for Primary Mitral Regurgitation in the Very Elderly.
Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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15 authors.
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Abstract
backgroundAdvanced age may influence the benefits derived from transcatheter edge-to-edge repair for primary mitral regurgitation (MR). We explored the impact of age on clinical, echocardiographic, functional, and patient-reported outcomes after contemporary mitral transcatheter edge-to-edge repair.
methodsPatients with primary MR were identified from a pooled, patient-level analysis of the EXPAND and EXPAND G4 studies. Key outcomes included 30-day and 1-year major adverse events, MR severity, New York Heart Association class, Kansas City Cardiomyopathy Questionnaire - Overall Summary score, and mortality.
resultsA total of 854 patients were included. The oldest quartile ranged in age from 86 to 99 years, while the younger quartiles ranged from 21 to 85 years. The 30-day major adverse events rate was not different in the oldest compared with the younger quartiles (5.7% versus 4.3%,
conclusionsAlthough 1-year mortality was higher among the very elderly, mitral transcatheter edge-to-edge repair using next-generation devices was associated with low complication rates and substantial improvements in ventricular remodeling, functional status, and quality of life across age groups. These findings support the use of mitral transcatheter edge-to-edge repair in appropriately selected elderly patients and suggest that age alone should not be a barrier to treatment.
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