ReviewJournal of cutaneous medicine and surgery
A Review of Post-Inflammatory Pigmentation Changes: Pathophysiology, Diagnosis and Treatment.
Review in Journal of cutaneous medicine and surgery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Post-inflammatory hyperpigmentation (PIH) and hypopigmentation are heterogenous conditions that often occur secondary to dermatoses (eg, psoriasis, acne, or atopic dermatitis), cutaneous injury (eg, burns or radiation therapy), infection (viral, bacterial, or fungal), or allergic/immunologic dysregulation (eg, contact dermatitis or insect bite reactions). The pathophysiology of PIH is complex with multiple pathways implicated in hypermelanosis including ultraviolet radiation exposure, local skin inflammation, and cytokine and growth factor signalling between keratinocytes, melanocytes, and dermal fibroblasts. PIH is a clinical diagnosis based on patient history and clinical examination and may persist for months to years following the resolution of underlying pathophysiological mechanisms, emphasizing the need for prompt diagnosis and management. PIH can be disfiguring and associated with substantial impairments in quality of life and psychosocial well-being. Patients with skin of colour (ie, Fitzpatrick skin types III-VI) have an increased risk of PIH and often present with more pronounced dyspigmentation, highlighting a high unmet need for improved recognition, awareness, and management in this population. Photoprotection is the cornerstone of PIH management given the photosensitive nature of the condition and is recommended in tandem with other treatment options including topical agents (eg, hydroquinone, retinoids, tranexamic acid), light/laser-based therapies, or chemical peels (glycolic acid and salicylic acid). Despite their use, high-level clinical evidence for these treatment options in PIH remains limited. This review provides an up-to-date overview of PIH pathophysiology, diagnosis and differential diagnosis, and management, and offers expert clinical commentary on practical strategies for identifying, preventing, and managing PIH in routine practice.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.