ArticleImmunity, inflammation and disease2026
Subsequent SARS-CoV-2 Infection in Healthcare Workers: A Retrospective Cohort Study in Iran.
Article in Immunity, inflammation and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
backgroundThe evolution of SARS-CoV-2 has increased global COVID-19 case prevalence. Healthcare workers (HCWs) are particularly susceptible to reinfection due to their exposure to infected patients. This study aimed to explore the risk factors for subsequent SARS-CoV-2 infection among HCWs.
methodsThis retrospective study was conducted in a teaching hospital affiliated with the Iran University of Medical Sciences between March 2021 and October 2021. HCWs completed an online survey to gather information about their COVID-19 infection history. Subsequent SARS-CoV-2 infection was defined as two or more infections, regardless of the time frame interval. Individuals who experienced a second infection within 90 days of the initial infection were considered to have a recurrence, and others were considered to have a reinfection. The generalized estimation equation was utilized to develop a multivariable prediction model.
resultsA total of 601 HCWs (60.2% female), mostly aged 18-29 years (47.4%), participated in this study. We observed 90 episodes of subsequent SARS-CoV-2 infection among HCWs, including 72 individuals (11.98%). Among them, 9 participants (1.5%) experienced recurrence, while 43 participants (7.1%) reported reinfection. In the multivariable analysis, vaccination significantly reduced the risk of subsequent SARS-CoV-2 infection, whereas nurses and those working in COVID-19 wards faced twice the risk.
conclusionThe frequency of subsequent SARS-CoV-2 infection is significant among HCWs. Vaccination status, occupation type, and workplace are key factors influencing the risk of future infections.
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