Evidence map›Paper›PMID 41847917›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Distinct Biotypes of Visual Perception in Major Depressive Disorder.

Zhuoran Cai, Xi-Wen Hu, Yuyang Li, Zheng Lin, Yongjie Li, Yong-Chun Cai, Tao Xu, Ke Jia, Jin-Fang Han, Zhong-Lin Tan and 4 more

Abstract read
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Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Zhuoran CaiSchool of Medicine, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University, Hangzhou, China.
Xi-Wen HuSchool of Medicine, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University, Hangzhou, China.
Yuyang LiSchool of Medicine, Department of Psychiatry of the Second Affiliated Hospital, Zhejiang University, Hangzhou, China.
Zheng LinSchool of Medicine, Department of Psychiatry of the Second Affiliated Hospital, Zhejiang University, Hangzhou, China.
Yongjie LiMOE Key Laboratory For Neuroinformation, The Clinical Hospital of Chengdu Brain Science Institute, University of Electronic Science and Technology of China, Chengdu, China.
Yong-Chun CaiDepartment of Psychology and Behavioral Sciences, Zhejiang University, Hangzhou, China.
Tao XuState Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Ke JiaSchool of Medicine, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University, Hangzhou, China.
Jin-Fang HanSchool of Medicine, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University, Hangzhou, China.
Zhong-Lin TanSchool of Medicine, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University, Hangzhou, China.
Dezhong YaoMOE Key Laboratory For Neuroinformation, The Clinical Hospital of Chengdu Brain Science Institute, University of Electronic Science and Technology of China, Chengdu, China.ORCID https://orcid.org/0000-0002-8042-879X
Xue Mei SongSchool of Medicine, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University, Hangzhou, China.
Sugai LiangSchool of Medicine, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University, Hangzhou, China.ORCID https://orcid.org/0000-0002-9873-1199
Georg NorthoffUniversity of Ottawa Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada.

Funding

Construction Fund of Key Medical Disciplines of HangzhouST1 2030-Major Projects 2022ZD0208500Zhejiang Provincial Natural Science Foundation LTGY23C090002Zhejiang Provincial Natural Science Foundation LTGY24H090012Zhejiang Provincial Program for the Cultivation of High-level Innovative Health talents
6 · The paper itself

Abstract

Previous studies showed abnormalities in both visual motion perception (VMP) and occipital cortex activity in subjects suffering from major depressive disorder (MDD). Can the psychophysical and/or neural markers of visual perception serve for clinical identification of MDD subgroups? To address this yet unresolved issue, we develope a novel analytical framework combining visual perceptual measurement with machine learning clustering to identify MDD subgroups. Within a cohort of 272 individuals with acute MDD, this approach reveals a VMP-positive (VMP-P) biotype characterized by impaired VMP. Clinically, this biotype exhibits significant cognitive deficits. We validate the robustness of this biotype through cross-validation and confirm its generalizability in an independent sample (n = 63). Furthermore, 7T MRI implicate aberrant neural activity in the occipital cortex as a mechanism underlying the VMP-P biotype. Our findings establish a novel, clinically translatable path for stratifying MDD, which can guide treatment development and advance precision medicine.

Indexed as

Major Depressive DisorderMotion PerceptionOccipital LobeVisual PerceptionAdultFemaleHumansMachine LearningMagnetic Resonance ImagingMaleMiddle Agedbiotypemachine learning clusteringmajor depressive disorderoccipital cortexvisual motion perception

Identifiers

PMID41847917
PMCPMC13587965

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.