Evidence map›Paper›PMID 41847914›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

A Dual-Responsive Versatile Nanohybrid Orchestrating Tumor Elimination and Tumor-Associated Osteolysis Restoration via Sequential Release.

Lan Liu, Han-Zhe Liu, Zhe-Nan Liu, Tong Wang, Li-Li Yu, Qiu-Jing Li, Zi-Yi Chen, Guo-Feng Luo, Zheng-Jun Shang

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lan LiuState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Hubei Key Laboratory of Stomatology, Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, P. R. China.
Han-Zhe LiuState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Hubei Key Laboratory of Stomatology, Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, P. R. China.
Zhe-Nan LiuState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Hubei Key Laboratory of Stomatology, Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, P. R. China.
Tong WangState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Hubei Key Laboratory of Stomatology, Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, P. R. China.
Li-Li YuState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Hubei Key Laboratory of Stomatology, Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, P. R. China.
Qiu-Jing LiState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Hubei Key Laboratory of Stomatology, Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, P. R. China.
Zi-Yi ChenState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Hubei Key Laboratory of Stomatology, Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, P. R. China.
Guo-Feng LuoState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Hubei Key Laboratory of Stomatology, Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, P. R. China.ORCID https://orcid.org/0000-0003-0431-1263
Zheng-Jun ShangState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Hubei Key Laboratory of Stomatology, Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, P. R. China.

Funding

National Natural Science Foundation of China 52473279,52303205,81972547.
6 · The paper itself

Abstract

Tumor-associated bone invasion often occurs in aggressive tumors and strongly compromises the efficacy of tumor treatment, which makes it challenging for comprehensive tumor therapy, highlighting the importance of simultaneous tumor elimination and tumor-associated osteolysis restoration. To achieve this goal, this study reports a versatile nanohybrid (CaO

Indexed as

Bone NeoplasmsOsteolysisAnimalsCell Line, TumorHumansHyaluronic AcidMiceOsteogenesisHyaluronic Acidbone regenerationion‐driven synergistic therapysequential releasetumor‐associated bone invasionversatile nanohybrid

Identifiers

PMID41847914
PMCPMC13248762

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.