Evidence map›Paper›PMID 41847891›Full record

ArticleThe Journal of dermatology2026

Circumscribed Morphea Successfully Treated With Excimer Laser: Analysis of Histopathological Changes.

Takuya Takahashi, Takehiro Takahashi, Yuichiro Segawa, Kenta Oka, Toshiya Takahashi, Yoshihide Asano

Abstract readCase Reports
In one paragraph

Article in The Journal of dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Takuya TakahashiDepartment of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.ORCID https://orcid.org/0009-0008-0927-6616
Takehiro TakahashiDepartment of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.ORCID https://orcid.org/0000-0002-1061-356X
Yuichiro SegawaDepartment of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Kenta OkaDepartment of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Toshiya TakahashiDepartment of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.ORCID https://orcid.org/0000-0001-9742-2282
Yoshihide AsanoDepartment of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.ORCID https://orcid.org/0000-0001-5560-9778

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Localized scleroderma (LSc) is an autoimmune condition characterized by localized cutaneous sclerosis, sometimes extending into deeper tissues. Phototherapy, including excimer laser therapy (ELT), is considered an effective and minimally invasive treatment option for patients without extracutaneous involvement. However, little is known about the histopathological and molecular alterations that occur during treatment. Here, we report a case of circumscribed morphea successfully treated with ELT, accompanied by detailed longitudinal histological analysis. A 78-year-old woman presented with gradually progressive indurated plaques on both sides of the abdomen. Histopathological examination of the lesional skin revealed dense collagen deposition and perivascular infiltration of lymphocytes, monocytes, and mast cells, confirming the diagnosis of circumscribed morphea. Topical glucocorticoid therapy yielded insufficient improvement, prompting the addition of 308-nm ELT. The patient underwent 12 ELT sessions, administered every two to four weeks with incremental dosing from 100 mJ/cm

Indexed as

Lasers, ExcimerLow-Level Light TherapyScleroderma, LocalizedSkinAgedBiopsyFemaleHumansMast CellsTreatment Outcomecircumscribed morpheaexcimer laserlocalized sclerodermaphototherapy

Identifiers

PMID41847891
PMCPMC13075530

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.