SynthesisBiomolecules & biomedicine2026
Polycystic ovary syndrome and risk of endometrial hyperplasia and endometrial cancer in women with abnormal uterine bleeding: A systematic review and meta-analysis.
Synthesis in Biomolecules & biomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder and a recognized risk factor for endometrial abnormalities. However, the relationship between PCOS and the development of endometrial hyperplasia (EH) and cancer (EC) in women experiencing abnormal uterine bleeding (AUB) remains inadequately defined. This meta-analysis aimed to assess the association between PCOS and the risk of EH/EC in this demographic. We conducted a systematic search of PubMed, Embase, and Web of Science from their inception until September 15, 2025. Observational studies comparing the risk of EH and/or EC in women with AUB and PCOS to those without PCOS were included. We utilized a random-effects model to pool data, estimating odds ratios (ORs) and 95% confidence intervals (CIs). Subgroup and sensitivity analyses were performed to evaluate the robustness of the findings and identify potential modifiers. A total of nine retrospective studies involving 6,064 women with AUB were included in this analysis. Among them, 462 (7.6%) had PCOS, while 704 (11.6%) were diagnosed with EH and/or EC. Our results indicated a significant association between PCOS and an increased risk of EH/EC (OR: 3.28, 95% CI: 2.54-4.25; I² = 0%, p < 0.001). This association remained consistent across sensitivity analyses and various subgroups defined by geographic region, menopausal status, analytic model, and study quality. Further analyses demonstrated heightened risks for EH (OR: 3.09, 95% CI: 2.49-3.82, p < 0.001) and EC (OR: 6.98, 95% CI: 4.68-10.40, p < 0.001) in women with PCOS. In conclusion, PCOS is associated with a significantly elevated risk of EH and EC in women with AUB. These findings underscore the necessity for enhanced endometrial surveillance in this high-risk population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.