Evidence map›Paper›PMID 41847730›Full record

ReviewJournal of Zhejiang University. Science. B2025

Recent research advances in the biological function and molecular mechanism of methylmalonic acid.

Zi'ang Wang, Wenhui Cheng, Teng Wang, Yidi Zhang, Xin'e Shi, Yuqi Lv, Jianjun Jin

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of Zhejiang University. Science. B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zi'ang WangLaboratory of Animal Fat Deposition and Muscle Development, Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
Wenhui ChengLaboratory of Animal Fat Deposition and Muscle Development, Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
Teng WangLaboratory of Animal Fat Deposition and Muscle Development, Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
Yidi ZhangLaboratory of Animal Fat Deposition and Muscle Development, Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
Xin'e ShiLaboratory of Animal Fat Deposition and Muscle Development, Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
Yuqi LvCollege of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China. jinjianjun2021@nwafu.edu.cn, lvyuqi@nwafu.edu.cn.
Jianjun JinLaboratory of Animal Fat Deposition and Muscle Development, Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China. jinjianjun2021@nwafu.edu.cn.

Funding

the Fundamental Research Funds for the Central Universities Z1010422004the National Natural Science Foundation of China 31900448the Natural Science Foundation of Shanxi Province 2023-JC-QN-0243
6 · The paper itself

Abstract

The abnormal accumulation of methylmalonic acid (MMA), the leading cause of methylmalonic acidemia, can cause irreversible damage to the brain, kidney, and cardiovascular system. In addition, the accumulation of MMA in the blood has recently been associated with the occurrence of cancer, restricted bodily movement, and growth retardation. In this review, recent studies on the relationship between the metabolic abnormality of MMA and disease occurrence were summarized, concerning the brain, kidney, cardiovascular system, cancer, and skeletal muscles. It provides a theoretical basis and reference for further research and the treatment of MMA-related pathophysiological changes.

Indexed as

Amino Acid Metabolism, Inborn ErrorsMethylmalonic AcidAnimalsHumansNeoplasmsOxidative StressMethylmalonic AcidMethylmalonic acid (MMA)Mitochondrial dysfunctionMuscle atrophyOxidative stressPost-translational modification of protein

Identifiers

PMID41847730
PMCPMC12996862

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.