Evidence map›Paper›PMID 41847611›Full record

ArticleiScience2026

IRF6 induces endothelial dysfunction through the transcriptional activation of NDRG1 and aggravates low shear stress-mediated atherosclerosis.

Yong Chen, Yanchao Zhang, Shen Rui, Bo Dong, Xiangshan Xu, Yuanzhe Jin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yong ChenDepartment of Cardiology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning 110000, China.
Yanchao ZhangDepartment of Ultrasound, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning 110000, China.
Shen RuiDepartment of Cardiology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning 110000, China.
Bo DongDepartment of Cardiology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning 110000, China.
Xiangshan XuDepartment of Cardiology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning 110000, China.
Yuanzhe JinDepartment of Cardiology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning 110000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atherosclerosis (AS), a chronic inflammatory disorder initiated by vascular endothelial dysfunction (ED), is prominently triggered by hemodynamic low-shear stress (LSS). Interferon regulatory factor 6 (IRF6) is a transcription factor that regulates the inflammatory response following injury. In this work, the LSS-induced AS model was induced by the partial ligation of the left carotid artery in high-fat diet-fed ApoE

Indexed as

molecular mechanism of gene regulationmolecular networkmolecular physiology

Identifiers

PMID41847611
PMCPMC12989853

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.