Evidence map›Paper›PMID 41847608›Full record

ArticleiScience2026

Turtle genomic novelty is driven by the evolution of ecological robustness.

Jule Drewalowski, Yuejiao Huang, Wessel Mulder, David A Duchêne

Abstract read
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jule DrewalowskiDepartment of Biology, Faculty of Science, University of Copenhagen, 2100 Copenhagen, Denmark.
Yuejiao HuangGlobe Institute, Faculty of Health and Medical Sciences, University of Copenhagen, 1350 Copenhagen, Denmark.
Wessel MulderCenter for Macroecology Evolution and Climate, Globe Institute, University of Copenhagen, Copenhagen, Denmark.
David A DuchêneDepartment of Public Health, University of Copenhagen, 1353 Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Turtles are striking among vertebrates in their unique diversity of morphology, ecology, and life-history. A robust physiology is often seen as the primary driver of turtle evolution, and this is increasingly studied in comparative genomics frameworks. Here, we use a genomic-scale dataset from across turtles and a novel comparative method to examine the genomic forces driving evolution in the group. Our approach addresses the correlation structures across species and genes flexibly via Mahalanobis distances from gene-wise pairwise genetic matrices, relaxing the assumption of an overarching species phylogeny. Analysis of outliers in this space reveals that close relatives, notably Cryptodira and Emydidae, share the most accelerated genes, and functional enrichment further indicates that these genes are involved in stress tolerance and immunity. These results reinforce ecological robustness as a core adaptation in turtles, and point to neutral processes as contributing to the genes with accelerated evolution in animals.

Indexed as

Evolutionary biologyMolecular biologyZoology

Identifiers

PMID41847608
PMCPMC12989854

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.