Evidence map›Paper›PMID 41847594›Full record

ArticleTransplant international : official journal of the European Society for Organ Transplantation2026

CNI Trough Variability Does Not Reliably Reflect Medication Adherence: Insights From a 3-Year Follow-Up Study.

Claire Villeneuve, Jean-Phillipe Rerolle, Lionel Couzi, Pierre-Francois Westeel, Isabelle Etienne, Laure Esposito, Nassim Kamar, Mathias Büchler, Antoine Thierry, Pierre Marquet and 1 more

Abstract read
In one paragraph

Article in Transplant international : official journal of the European Society for Organ Transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Claire VilleneuveCHU Limoges, Department of Pharmacology, Toxicology and Centre of Pharmacovigilance, Limoges, France.
Jean-Phillipe RerolleINSERM, UMR-1248, Limoges, France.
Lionel CouziDepartment of Nephrology, Transplantation, Dialysis, Centre Hospitalier Universitaire (CHU) Pellegrin, Bordeaux, France.
Pierre-Francois WesteelDepartment of Nephrology and Kidney Transplantation, University Hospital of Amiens, Amiens, France.
Isabelle EtienneService de Nephrologie, Rouen University Hospital, Rouen, France.
Laure EspositoDepartment of Nephrology and Organ Transplantation, CHU Toulouse, Toulouse, France.
Nassim KamarDepartment of Nephrology and Organ Transplantation, CHU Toulouse, Toulouse, France.
Mathias BüchlerFHU SUPORT, Limoges, France.
Antoine ThierryFHU SUPORT, Limoges, France.
Pierre MarquetCHU Limoges, Department of Pharmacology, Toxicology and Centre of Pharmacovigilance, Limoges, France.
Caroline MonchaudCHU Limoges, Department of Pharmacology, Toxicology and Centre of Pharmacovigilance, Limoges, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calcineurin inhibitor (CNI) trough concentrations and their variability are frequently used as adherence proxies, despite limited validation. We evaluated the association between self-reported adherence and CNI exposure during the first year after kidney transplantation. We included 619 patients from two prospective French cohorts (14,829 C

Indexed as

Calcineurin InhibitorsDrug MonitoringImmunosuppressive AgentsKidney TransplantationMedication AdherenceAdultCross-Sectional StudiesFemaleFollow-Up StudiesFranceGraft RejectionHumansLongitudinal StudiesMaleMiddle AgedProspective StudiesCalcineurin InhibitorsImmunosuppressive AgentsTacrolimusadherencecalcineurin inhibitor (CNI)kidney transplantationtrough concentrations (C0)variability

Identifiers

PMID41847594
PMCPMC12989446

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.