ArticleRSC advances2026
Rational design and synthesis of non-competitive transcription inhibitors targeting a conserved RNA polymerase-σ
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
RNA polymerase (RNAP) inhibitors that block RNA chain elongation or disrupt DNA unwinding have long served as frontline therapeutic agents. However, a major limitation of competitive inhibitors like rifampicin is the rapid emergence of resistance due to point mutations at the RNAP active site. Transcription initiation, the first step in mRNA synthesis, depends on the interaction between RNAP and a sigma (σ) factor. We targeted the conserved region of the RNAP-σ
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