ArticleFrontiers in cardiovascular medicine2026
Thromboembolism in the left main coronary artery of a patient with membranous nephropathy: a case report.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Membranous nephropathy (MN) is the most common cause of nephrotic syndrome in adults and a well-established risk factor for hypercoagulability. Although venous thromboembolism is frequently documented, arterial thrombosis-particularly acute thrombosis of the left main coronary artery (LMCA)-remains exceedingly rare. Case presentation: We report a fatal case of a 48-year-old male with a 10-year history of MN who presented with intermittent chest pain for 17 h and a marked elevation in troponin levels. Emergency coronary angiography revealed extensive thrombosis in the LMCA. Despite thrombus aspiration and stent implantation, the patient developed refractory cardiogenic shock and died. Conclusion: Acute LMCA thrombosis associated with MN is a rare occurrence. This case highlights that the hypercoagulable state linked to MN is not confined to venous thromboembolic events and may, in rare instances, lead to fatal arterial thrombosis.
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