ArticleFrontiers in cardiovascular medicine2026
A refined approach of the tachypacing porcine model of heart failure.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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12 authors.
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Abstract
Background: Preclinical models of heart failure (HF) play a key role in developing new therapeutic strategies. Tachypacing is the gold standard to induce dilated cardiomyopathy (DCM) with reduced ejection fraction (EF) in large animals, but it is not exempted from failures and can induce relevant stress. Aim: Establishing a revised porcine model of tachypacing-induced HF to improve reliability and reduce stress on the animals. Methods: Eight ( Results: Echocardiographic assessment showed that all paced animals developed stable DCM as demonstrated by increase of end-systolic and end-diastolic volume at highly depressed ejection fraction. Invasive measurements confirmed these results with stable mAOP despite impaired pump function. JET showed no alterations of respiratory rate and daily activity throughout the protocol. Cortisol and cortisone levels and body weight showed no significant differences between groups or during pacing. Conclusions: We established a reliable model of tachypacing-induced HF based on slower pacing and milder progression to HF, while reducing the stress and suffering of the animals.
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