ArticleFrontiers in pediatrics2026
Interaction of intrauterine Zika virus exposure on the relationship between body adiposity and dyslipidemia in school-aged children.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction/objectives: Intrauterine exposure to the Zika virus (ZIKV) has been primarily associated with neurological outcomes, while its potential metabolic and nutritional consequences remain poorly understood. This study aimed to evaluate the association between anthropometric indicators body mass index (BMI)-for-age, waist circumference, and neck circumference and lipid profile alterations in school-aged children born during the ZIKV epidemic. Methods: This retrospective cohort included 93 children aged 5-9 years (mean 6.5 ± 0.7 years; 58.1% boys) from the Belo Horizonte Region, Brazil. Participants were classified as exposed (59.1%) or unexposed to ZIKV Results: Lipid abnormalities were common: low HDL-c (44.1%), high total cholesterol (33.3%), high LDL-c (26.9%), and high triglycerides (44.1%). Children exposed to ZIKV had a higher prevalence of low HDL-c compared with unexposed peers (54.6% vs. 29.0%; Conclusions: Intrauterine ZIKV exposure influences the relationship between adiposity and lipid profile in children. Central adiposity measures including waist circumference, neck circumference, and BMI-provide complementary information for early metabolic risk assessment. These findings highlight the importance of longitudinal monitoring of children exposed to ZIKV
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