ArticleThe Canadian veterinary journal = La revue veterinaire canadienne2026
Potential acute hepatic injury in 2 cats exposed to topical human diclofenac.
Article in The Canadian veterinary journal = La revue veterinaire canadienne, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two domestic shorthair cats from the same household developed acute liver injury with exposure to human transdermal diclofenac cream. A 7-year-old spayed female cat (Cat 1) was brought to the Western College of Veterinary Medicine (Saskatoon, Saskatchewan) with anorexia, lethargy, and fever. The cat had markedly elevated ALT (10 549 U/L) and glutamate dehydrogenase (1456 U/L), and hyperbilirubinemia (total bilirubin: 16.7 μmol/L). Cat 1 improved with supportive care and was discharged. The following day, a 6-year-old spayed female cat (Cat 2) was presented with anorexia and lethargy. Laboratory tests also showed severe hepatocellular injury (ALT: 20 838 U/L, glutamate dehydrogenase: 2054 U/L) and hyperbilirubinemia (total bilirubin: 26.7 μmol/L). A blood smear revealed green to dark-blue cytoplasmic material in neutrophils, consistent with "critical green inclusions" in humans. Cat 2 developed progressive clinical deterioration and was euthanized. The caregiver reported having used 10% diclofenac cream for 3 mo. Drug screening
Indexed as
Identifiers
41847487PMC12990017What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.