Evidence map›Paper›PMID 41847434›Full record

ArticleLife metabolism2026

Deletion of hepatic growth hormone receptor contributes to the pathogenesis of lean MAFLD by elevating CD36.

Dong Yu, Xiao Yang, Xiaonan Zhang, Xiaoxin Wang, Zicheng Pu, Ai Mi, Liyuan Ran, Fang Zhang, Bin Liang, Yingjie Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dong YuInstitute of Genome Engineered Animal Models for Human Diseases, National Center of Genetically Engineered Animal Models for International Research, Liaoning Province Key Lab of Genome Engineered Animal Models, Dalian Medical University, Dalian, Liaoning 116044, China.
Xiao YangKey Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Shandong Provincial Hospital, Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250021, China.
Xiaonan ZhangInstitute of Genome Engineered Animal Models for Human Diseases, National Center of Genetically Engineered Animal Models for International Research, Liaoning Province Key Lab of Genome Engineered Animal Models, Dalian Medical University, Dalian, Liaoning 116044, China.
Xiaoxin WangInstitute of Genome Engineered Animal Models for Human Diseases, National Center of Genetically Engineered Animal Models for International Research, Liaoning Province Key Lab of Genome Engineered Animal Models, Dalian Medical University, Dalian, Liaoning 116044, China.
Zicheng PuInstitute of Genome Engineered Animal Models for Human Diseases, National Center of Genetically Engineered Animal Models for International Research, Liaoning Province Key Lab of Genome Engineered Animal Models, Dalian Medical University, Dalian, Liaoning 116044, China.
Ai MiInstitute of Genome Engineered Animal Models for Human Diseases, National Center of Genetically Engineered Animal Models for International Research, Liaoning Province Key Lab of Genome Engineered Animal Models, Dalian Medical University, Dalian, Liaoning 116044, China.
Liyuan RanInstitute of Genome Engineered Animal Models for Human Diseases, National Center of Genetically Engineered Animal Models for International Research, Liaoning Province Key Lab of Genome Engineered Animal Models, Dalian Medical University, Dalian, Liaoning 116044, China.
Fang ZhangNational Clinical Research Center for Eye Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
Bin LiangCenter for Life Sciences, School of Life Sciences, Yunnan University, Kunming, Yunnan 650091, China.
Yingjie WuInstitute of Genome Engineered Animal Models for Human Diseases, National Center of Genetically Engineered Animal Models for International Research, Liaoning Province Key Lab of Genome Engineered Animal Models, Dalian Medical University, Dalian, Liaoning 116044, China.ORCID https://orcid.org/0000-0002-2694-1971

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic dysfunction-associated fatty liver disease (MAFLD) has become the most prevalent chronic liver disease worldwide, affecting both obese and non-obese individuals. While the reduced levels of circulating growth hormone (GH) and insulin-like growth factor 1 (IGF-1) have been consistently observed in patients with hepatic steatosis, the molecular role of hepatic growth hormone receptor (GHR) in MAFLD pathogenesis remains unclear. In this study, we established a liver-specific

Indexed as

growth hormone receptorlean body massliver GHRKOMAFLD

Identifiers

PMID41847434
PMCPMC12990309

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.