ArticleJournal of inflammation research2026
Neutrophil Percentage-to-Albumin Ratio is Associated with Functional Outcome, Hematoma Clearance, and Peak Perihematomal Edema in Supratentorial Intracerebral Hemorrhage.
Article in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Purpose: Although inflammatory markers have been implicated in the prognosis of intracerebral hemorrhage (ICH), their associations with peak perihematomal edema (PHE) and hematoma clearance remain unclear. This study evaluated inflammatory markers, focusing on the neutrophil percentage-to-albumin ratio (NPAR), to determine their prognostic relevance in supratentorial ICH. Patients and Methods: We retrospectively analyzed patients with supratentorial ICH who arrived at Beijing Tiantan Hospital within 24h of symptom onset between January 2021 and December 2022. Both inflammatory and imaging markers were measured at multiple time points. Hematoma and PHE volumes were quantified using Results: A total of 470 patients were included. LASSO regression identified NPAR as the strongest inflammation-related predictor of 90-day outcome. Higher admission NPAR independently related with greater peak PHE (r = 0.15, Conclusion: NPAR was independently associated with poor functional outcome and greater peak PHE, while also being associated with hematoma clearance dynamics, highlighting the complex relationship between systemic inflammation, host reserve, and recovery processes in supratentorial ICH.
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