ArticleNature and science of sleep2026
Gerontological Effects on Arousal Frequency, Autonomic Balance, and Slow-Wave Sleep During Pressure Adjustments of CPAP in OSA Patients.
Article in Nature and science of sleep, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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13 authors.
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Abstract
Objective: Continuous positive airway pressure (CPAP) therapy is recognized as first-line treatment for obstructive sleep apnea (OSA), but tolerance to pressure adjustments may differ with age. In this study, we examined age-related differences in physiological and neurophysiological responses following CPAP pressure adjustment. Methods: In this retrospective study, we analyzed baseline polysomnography (PSG) and CPAP titration data from 40 individuals, including 20 younger (<65 years) and 20 older adults (≥65 years) matched at the group level. Time-specific analyses were conducted using 10-min windows following pressure adjustments. Group comparisons across predefined pressure categories of CPAP (4-5, 6-7, and ≥ 8 cmH Results: Both age groups demonstrated improvements in sleep architecture and sleep disorder indices during CPAP titration. Among older individuals, analyses of 10-min periods following pressure adjustments showed a higher arousal frequency, increased elevated standard deviation (SD) of normal-to-normal (NN) intervals (SDNN) and low-frequency (LF)/high-frequency (HF) ratios, and reduced slow-wave peak-to-peak amplitudes and slopes compared to younger counterparts. Regression analyses further indicated associations between pressure categories, HRV features, and slow-wave characteristics in the elderly group. Conclusion: These findings highlight potential age-related differences in short-term responses to pressure adjustments for CPAP. Future prospective studies are needed to validate and enhance the generalizability and robustness of these findings.
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