Observational studyInternational journal of chronic obstructive pulmonary disease2026
Association Between Peripheral Blood NLR, PLR, and EXACT-PRO Scores in Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Prospective Observational Cohort Study.
Observational study in International journal of chronic obstructive pulmonary disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Carbon Emissions and Treatment Efficiency in Chronic Obstructive Pulmonary Disease: The Impact of Inhaled Bronchodilators and Corticosteroids.International journal of chronic obstructive pulmonary disease · 2026Observational
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Authors and funding
3 authors.
Funding
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Abstract
Objective: This study examined the correlation between changes in peripheral blood neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) before and after treatment, and Exacerbations of Chronic Pulmonary Disease Tool - Patient Reported Outcome (EXACT-PRO) scores in patients with acute exacerbations of COPD (AECOPD), to assess the clinical utility of EXACT-PRO in measuring disease severity. Methods: Hospitalized patients diagnosed with AECOPD underwent pulmonary function testing, and peripheral blood NLR and PLR levels were recorded before and after treatment. Participants completed the EXACT-PRO, COPD Assessment Test (CAT), and modified Medical Research Council (mMRC) Dyspnea Scale questionnaires. Patients with AECOPD were classified into mild, moderate, and severe groups according to the 2026 GOLD classification criteria. Baseline characteristics were compared across the three groups. Pearson's correlation analysis was performed to evaluate the relationship between changes in NLR, PLR, and EXACT-PRO scores. ROC curves of post-treatment NLR and EXACT-PRO scores were further constructed to evaluate the discriminative performance of NLR, and a scatter plot was used to visually illustrate the correlation between the two variables. Results: After applying the exclusion criteria to the initial cohort of 112 patients, a total of 60 patients with AECOPD were ultimately included in the analysis. According to the 2026 GOLD classification criteria, 13 patients were classified as mild, 29 as moderate, and 18 as severe. Blood samples were collected within 24 hours of hospital admission before treatment and on the day of discharge after treatment. Post-treatment NLR levels showed a statistically significant reduction compared to pre-treatment levels ( Conclusion: Peripheral blood NLR levels demonstrated potential clinical relevance in patients with AECOPD and may support the development of a simple and effective quantitative tool for assessing disease severity.
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