Evidence map›Paper›PMID 41847321›Full record

ArticleIJTLD open2026

Ultrasound dynamics during treatment of pulmonary and extra-pulmonary TB.

S F Weber, F Tobian, M Gaeddert, R Wolf, K Manten, D Shankar, B Thangakunam, B Isaac, A K Dutta, N Wetzstein and 9 more

Abstract read
In one paragraph

Article in IJTLD open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

S F WeberDepartment of Infectious Disease and Tropical Medicine, Heidelberg University Hospital, Heidelberg, Germany.ORCID https://orcid.org/0000-0003-2139-737X
F TobianDepartment of Infectious Disease and Tropical Medicine, Heidelberg University Hospital, Heidelberg, Germany.
M GaeddertDepartment of Infectious Disease and Tropical Medicine, Heidelberg University Hospital, Heidelberg, Germany.
R WolfDepartment of Infectious Disease and Tropical Medicine, Heidelberg University Hospital, Heidelberg, Germany.
K MantenDepartment of Anesthesiology, Heidelberg University Hospital, Heidelberg, Germany.
D ShankarDepartment of Pulmonary Medicine, Christian Medical College Vellore, Vellore, India.
B ThangakunamDepartment of Pulmonary Medicine, Christian Medical College Vellore, Vellore, India.
B IsaacDepartment of Pulmonary Medicine, Christian Medical College Vellore, Vellore, India.
A K DuttaDepartment of Clinical Gastroenterology, Christian Medical College Vellore, Vellore, India.
N WetzsteinDepartment II of Internal Medicine, Infectious Diseases, Goethe University Frankfurt, University Hospital Frankfurt, Frankfurt am Main, Germany.
M J G T VehreschildDepartment II of Internal Medicine, Infectious Diseases, Goethe University Frankfurt, University Hospital Frankfurt, Frankfurt am Main, Germany.
I SuárezDepartment I of Internal Medicine, Division of Infectious Diseases, Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany.
J RybnikerDepartment I of Internal Medicine, Division of Infectious Diseases, Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany.
P WolfDepartment for Pneumology and Critical Care Medicine, Thoraxklinik Heidelberg, Heidelberg, Germany.
F HerthDepartment for Pneumology and Critical Care Medicine, Thoraxklinik Heidelberg, Heidelberg, Germany.
S BélardInstitute of Tropical Medicine, University of Tübingen, Tübingen, Germany.ORCID https://orcid.org/0000-0002-2008-418X
D J ChristopherDepartment of Pulmonary Medicine, Christian Medical College Vellore, Vellore, India.ORCID https://orcid.org/0000-0002-9405-8494
C M DenkingerDepartment of Infectious Disease and Tropical Medicine, Heidelberg University Hospital, Heidelberg, Germany.ORCID https://orcid.org/0000-0002-7216-7067
ALL POCUS TB Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPoint-of-care ultrasound (POCUS) offers an accessible tool for TB screening, particularly in resource-limited settings. Data on the longitudinal dynamics of sonographic pulmonary (PTB) and extra-pulmonary TB (EPTB) findings during anti-TB treatment (ATT) for potential therapy monitoring remain limited.

methodsThis secondary analysis of a prospective, multi-centre accuracy study of adults with presumed TB at one Indian and three German referral hospitals followed up participants undergoing ATT. Participants underwent lung (LUS) and extra-pulmonary ultrasound for pleural effusions, lymphadenopathy (peripheral, abdominal, internal mammary), ascites, and peritoneal pathology, before and during ATT. LUS findings were calculated as a score and compared between time-points.

results71 participants were enrolled from January 2022 to July 2023; most had pulmonary pathology (n = 68) or pleural effusion (n = 33). Median LUS scores declined consistently to 86% after 2-3 months of ATT compared to baseline. After 6-8 months, median LUS score was 47%, suggesting persistence of pathology. Pleural effusion showed improvements after 2-3 months in 30%, and peripheral lymphadenopathy persisted in 33% even after ATT completion.

conclusionSonographic findings in TB typically resolved with ATT but resolution may be incomplete even after 6 months. This study provides evidence supporting the potential role of ultrasound monitoring for the response of TB to ATT.

Indexed as

GermanyIndiaparadoxical reactionpoint-of-care ultrasoundTB sequelaetreatment monitoringtuberculosis

Identifiers

PMID41847321
PMCPMC12991774

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.