ArticleDrug design, development and therapy2026
Nanoencapsulated α-Mangostin Loaded Chitosan-Alginate Hydrogel Films for Enhanced Topical Anti Acne Therapy.
Article in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Data Interpretation Paradoxes in a Nanoencapsulated α-Mangostin Hydrogel Film for Anti-Acne Therapy [Letter].Drug design, development and therapy · 2026Article
- Data Interpretation Paradoxes in a Nanoencapsulated α-Mangostin Hydrogel Film for Anti-Acne Therapy [Response to Letter].Drug design, development and therapy · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: α-Mangostin (α-M) is a natural antimicrobial and anti-inflammatory compound with promising anti-acne potential; however, its poor solubility and instability limit its topical use. This study developed and evaluated chitosan-alginate hydrogel films incorporating nanoencapsulated α-M (HF α-M NPs) to enhance stability, skin penetration, and therapeutic efficacy against Methods: α-M NPs were produced by ionic gelation using chitosan and sodium tripolyphosphate, followed by alginate coating, and subsequently incorporated into chitosan-alginate hydrogel films. Nanoparticles and films were characterized using SEM, FTIR, mechanical testing, swelling behavior, degradability analysis, and in vitro drug-release studies. The anti-acne performance was assessed in a Results: The nanoparticles exhibited a mean size of 229.7 ± 18.15 nm, PDI of 0.450 ± 0.046, and zeta potential of +40.9 ± 1.91 mV, indicating strong colloidal stability. SEM confirmed the uniform distribution of nanoparticle in the hydrogel matrix, while FTIR revealed molecular interactions between the polymers and α-M. HF α-M NPs showed improved mechanical strength, controlled swelling, and a sustained release profile compared with free α-M films. In vivo, the HF α-M NPs achieved the greatest reduction in Conclusion: Nanoencapsulation of α-M within a chitosan-alginate hydrogel matrix significantly enhanced its stability, release behavior, and antimicrobial and anti-inflammatory effects. HF α-M NPs represents a promising antibiotic free topical therapy for acne and merits further optimization and clinical investigation.
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