Evidence map›Paper›PMID 41847179›Full record

ReviewInternational journal of nanomedicine2026

Nanotechnology-Enabled Diagnosis and Treatment of Hepatocellular Carcinoma: Theranostics, Combination Regimens, and Translation.

Siyao Wang, Yang Wu, Miao Yuan, Jing Zheng, Chaoran Wang, Jiarong Wang, Yifan Zheng, Qiaoyun Yang, Mengran Xu, Baiqi Wang

Abstract readReview
In one paragraph

Review in International journal of nanomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Siyao Wang *Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin, People's Republic of China.
Yang Wu *Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin, People's Republic of China.
Miao Yuan *Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin, People's Republic of China.
Jing ZhengDepartment of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin, People's Republic of China.
Chaoran WangDepartment of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin, People's Republic of China.
Jiarong WangDepartment of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin, People's Republic of China.
Yifan ZhengDepartment of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin, People's Republic of China.
Qiaoyun YangDepartment of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin, People's Republic of China.
Mengran XuDepartment of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin, People's Republic of China.
Baiqi WangDepartment of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin, People's Republic of China.ORCID 0000-0001-7769-1514

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This manuscript explores the innovative application of nanotechnology in the diagnosis and treatment of hepatocellular carcinoma (HCC), a leading cause of cancer-related mortality worldwide. Emphasizing the synergistic potential of nanotechnology, the paper discusses advanced nanomaterials and techniques, such as targeted drug delivery systems, nanoparticle-based imaging, and multi-modal therapy, which enhance the precision and efficacy of HCC interventions. Nanotechnology offers significant improvements in early diagnosis through enhanced imaging capabilities and tumor-specific biomarkers, enabling more accurate detection of HCC at its early stages. Furthermore, it enables the development of novel therapeutic strategies, including the targeted delivery of chemotherapeutic agents, gene therapies, and immunotherapies, minimizing side effects and improving patient outcomes. The manuscript also highlights challenges such as bio-barrier penetration, biocompatibility, and the high production costs associated with nanomedicine. Despite these obstacles, the integration of nanotechnology with artificial intelligence and personalized medicine promises a transformative future for HCC treatment. This review underscores the pivotal role of nanotechnology in advancing both the diagnostic and therapeutic landscapes for HCC, offering a new frontier for improving survival rates and quality of life for patients.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsNanotechnologyTheranostic NanomedicineAnimalsAntineoplastic AgentsCombined Modality TherapyDrug Delivery SystemsHumansNanomedicineNanoparticlesPrecision MedicineAntineoplastic Agentsdiagnosishepatocellular carcinomamultimodalitynanotechnologytreatment

Identifiers

PMID41847179
PMCPMC12990915

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.