Evidence map›Paper›PMID 41847076›Full record

ArticleACG case reports journal2026

Inflammatory Hilar Mass and Cavernous Transformation in Disseminated Histoplasmosis: A Rare Cause of Noncirrhotic Portal Hypertension.

Katharine Tippins, Elizabeth C Townsend, Franklyn Wallace, Heip Phan, Charles T Rohrer, Adnan Said

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in ACG case reports journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Katharine TippinsDepartment of Medicine, University of Wisconsin, Madison, WI.
Elizabeth C TownsendMedical Scientist Training Program, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Franklyn WallaceGastroenterology and Hepatology, Department of Medicine, University of Wisconsin, Madison, WI.
Heip PhanGastroenterology and Hepatology, Department of Medicine, University of Wisconsin, Madison, WI.
Charles T RohrerPathology and Laboratory Medicine, Department of Medicine, University of Wisconsin, Madison, WI.
Adnan SaidGastroenterology and Hepatology, Department of Medicine, University of Wisconsin, Madison, WI.

Funding

Integrated Training For Physician-ScientistsT32GM140935 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher, Jeniel E Nett · 2021 to 2026
$6.5M
NIGMS NIH HHS T32 GM140935
6 · The paper itself

Abstract

Disseminated histoplasmosis is a fungal infection usually encountered in immunocompromised hosts. Hepatic involvement is common, but portal hypertension due to extrahepatic lymph node compression has not been described. We present a 68-year-old man without cirrhosis who developed noncirrhotic portal hypertension by reactive, fibrosing porta hepatis lymphadenopathy after disseminated histoplasmosis treatment. Despite prior exposure to immunosuppressive therapy for presumed sarcoidosis, liver biopsy demonstrated preserved hepatic architecture and normal hepatic venous pressure gradient, supporting a presinusoidal, extrahepatic mechanism. This case highlights a novel, compressive cause of noncirrhotic portal hypertension and underscores the importance of recognizing immune reconstitution inflammatory responses in disseminated histoplasmosis.

Indexed as

cavernous transformationhistoplasmosisimmune reconstitution inflammatory syndromeportal hypertension

Identifiers

PMID41847076
PMCPMC12991445

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.