Evidence map›Paper›PMID 41847033›Full record

ArticlebioRxiv : the preprint server for biology2026

Miniprotein inhibitors of the

Priyanka Mishra, Adam Chazin-Gray, Gaëlle Lamon, David Kim, David Baker, Nathaniel J Traaseth

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Priyanka MishraDepartment of Chemistry, New York University, New York, NY, USA.
Adam Chazin-GrayDepartment of Molecular Engineering, University of Washington, Seattle, WA, USA.
Gaëlle LamonDepartment of Chemistry, New York University, New York, NY, USA.
David KimInstitute for Protein Design, University of Washington, Seattle, WA, USA.ORCID 0000-0002-0023-956X
David BakerInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Nathaniel J TraasethDepartment of Chemistry, New York University, New York, NY, USA.ORCID 0000-0002-1185-6088

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARK Reid PHILIPS · 1985 to 2026
$83.1M
Mechanisms of Allostery and Molecular Recognition in the Small Multidrug Resistance FamilyR01AI108889 · NIAID · NEW YORK UNIVERSITY · PI Nathaniel J. Traaseth · 2014 to 2026
$5.4M
Transport Cycle and Inhibition of Human Na+-dicarboxylate Cotransporter NaDC3R01NS108151 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DANENG WANG · 2018 to 2026
$4.1M
Transport Mechanisms and Inhibition of Efflux Pumps in Pathogenic OrganismsR01AI165782 · NIAID · NEW YORK UNIVERSITY · PI SHOHEI KOIDE, Nathaniel J. Traaseth · 2022 to 2026
$4.0M
Discovery of efflux pump inhibitors using a high-throughout bacterial assayR21AI188334 · NIAID · NEW YORK UNIVERSITY · PI Nathaniel J. Traaseth · 2025 to 2026
$443k
NCI NIH HHS P30 CA016087NIAID NIH HHS R01 AI108889NIAID NIH HHS R01 AI165782NIAID NIH HHS R21 AI188334NINDS NIH HHS R01 NS108151
6 · The paper itself

Abstract

Multidrug efflux pumps transport antibiotics across the cellular membrane resulting in resistance conferred to the host organism. Efflux pump inhibitors (EPIs) potentiate the efficacy of antibiotics by blocking drug efflux and hold promise as adjuvant therapeutics in the fight against multidrug resistant pathogenic bacteria. A hurdle in the field has been the lack of selectivity of small molecule EPIs which often display off-target toxicity due to non-specific binding. To tackle this specificity challenge, we aimed to maximize an inhibitor's binding surface area to efflux pumps by designing miniprotein EPIs using computational protein design and an

Identifiers

PMID41847033
PMCPMC12991122

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.