Evidence map›Paper›PMID 41847019›Full record

ArticlebioRxiv : the preprint server for biology2026

Intestinal intraepithelial lymphocyte migration and tissue homeostasis are dictated by Gα13.

Zachary M Earley, Anshul Rao, Konrad Knöpper, Fanglue Peng, Longhui Qiu, Norihide Jo, Wioletta Lisicka, Hanna Taglinao, Jinping An, Ying Xu and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Zachary M EarleyORCID 0000-0001-9748-7262
Anshul Rao
Konrad Knöpper
Fanglue Peng
Longhui Qiu
Norihide Jo
Wioletta Lisicka
Hanna Taglinao
Jinping An
Ying Xu
Li V Yang
Dan Liu
Mark R Looney
Jason G Cyster

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The intestinal barrier harbors numerous intraepithelial lymphocytes (IEL) that promote tissue integrity and whose dysfunction contributes to disease. The signals regulating IEL dynamics are incompletely understood. Here we show that deficiency in heterotrimeric G-protein subunit Gα13 or effector Arhgef1 causes a loss of CD8αα and CD8αβ IEL. Following Gα13 ablation, IEL reduce migration speed prior to undergoing cell death. Induction of CD8αβ IEL by

Identifiers

PMID41847019
PMCPMC12991100

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.