Evidence map›Paper›PMID 41846999›Full record

ArticlebioRxiv : the preprint server for biology2026

Bacterial pyruvate metabolism regulates host insulin sensitivity in

Marco E Mechan-Llontop, Kelsie M Nauta, Darrick R Gates, Xiao Wang, Jason Cooper, Nicholas O Burton

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marco E Mechan-LlontopVan Andel Research Institute, Department of Metabolism and Nutritional Programing, Grand Rapids, MI, 49503, USA.
Kelsie M NautaVan Andel Research Institute, Department of Metabolism and Nutritional Programing, Grand Rapids, MI, 49503, USA.
Darrick R GatesVan Andel Research Institute, Department of Metabolism and Nutritional Programing, Grand Rapids, MI, 49503, USA.
Xiao WangVan Andel Research Institute, Department of Metabolism and Nutritional Programing, Grand Rapids, MI, 49503, USA.
Jason CooperVan Andel Research Institute, Department of Metabolism and Nutritional Programing, Grand Rapids, MI, 49503, USA.
Nicholas O BurtonVan Andel Research Institute, Department of Metabolism and Nutritional Programing, Grand Rapids, MI, 49503, USA.

Funding

IDENTIFYING MICROBIAL MECHANISMS THAT REGULATE ANIMAL INSULIN SIGNALINGDP2DK139569 · NIDDK · VAN ANDEL RESEARCH INSTITUTE · PI Nicholas O Burton · 2023 to 2026
$2.9M
NIDDK NIH HHS DP2 DK139569
6 · The paper itself

Abstract

Two different individuals can consume an identical diet but experience different physiological outcomes. While there are many potential mechanistic reasons for this, one increasingly recognized reason is that differences in an animal's microbiome can lead to differences in the processing of dietary nutrients. Thus, though a diet might start out the same, how it is experienced by a host is dependent on their microbiome. While exciting, mechanistic studies of diet-microbiome-host effects are often limited by the lack of high throughput laboratory techniques to identify and define interactions between dietary metabolites, microbial metabolism, and host biology. We hypothesized that the model organism

Indexed as

aceEC. elegansE. coli OP50fructoseglucosemetabolismmicrobiomepyruvatepyruvate dehydrogenase

Identifiers

PMID41846999
PMCPMC12991093

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.