Evidence map›Paper›PMID 41846978›Full record

ArticlebioRxiv : the preprint server for biology2026

Vps35 p. D620N causes Lrrk2 kinase hyperactivity, chronic microglial activation and inflammation.

Isaac Bul Deng, Mengfui Bu, Jordan Follett, Robert Sharp, Adamantois Mamais, Leyna Xoi, Fahong Yu, Georges Rabil, Shannon Wall, Matthew J Farrer

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Isaac Bul DengDepartment of Neurology, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA.
Mengfui BuDepartment of Neurology, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA.
Jordan FollettDepartment of Neurology, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA.
Robert SharpDepartment of Neurology, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA.
Adamantois MamaisDepartment of Neurology, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA.
Leyna XoiDepartment of Neurology, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA.
Fahong YuInterdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, Florida, USA.
Georges RabilDepartment of Neurology, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA.
Shannon WallDepartment of Neurology, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA.
Matthew J FarrerDepartment of Neurology, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA.ORCID 0000-0003-1159-5321

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathogenic variants in

Identifiers

PMID41846978
PMCPMC12990989

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.